Онлайн (Онлайн)ISSN 2313-1519
Баспалық (Печатный) ISSN 1812-2892
Тұжырымдама (Резюме) - Is there any relationship between hematologic parameters and presbyacusis in geriatric patients?
Zeynel Abidin Erkan, Gokhan Kuran


Aim: Presbycusis is the most common sensory deficit in the aging population. Blood examinations are inexpensive and simple methods for analyzing red cells, white cells and platelets for coagulation, inflammation, thrombosis. In the present study, we aimed to investigate the relationship between presbycusis and inflammatory and prothrombotic factors that can be measured routinely in complete blood count (CBC) tests with little cost in addition with hearing loss types.

Material and methods: The study was conducted prospectively. Group I comprised patients with presbycusis aged ≥65 years (n=31), group 2 was constituted by healthy volunteers aged ≥65 years (n=30). Audiograms were categorized according to hearing levels at 0.5, 1, 2, 4, and 8 kHz: high-frequency steeply sloping (HFSS), flat configuration, high-frequency gently sloping (HFGS). Complete blood counts including hemoglobin (Hb), RDW (red cell distribution width), WBC (white blood cell), neutrophil-to-lymphocyte ratio (NLR), platelets (PLT), platelet-to-lymphocyte ratio (PLR), PCT(procalcitonin), PDW (platelet distribution width), MPV (mean platelet volume), and fibrinogen were analyzed.

Results: There were no significant differences between the patient and control groups in terms of Hb, RDW, WBC, NLR, PLT, PCT, PDW, MPV, PLR and fibrinogen (p>0.05). There were no significant differences between the FLAT, HFSS and normal groups in terms of mean Hb, RDW, WBC, NLR, PLT, PCT, PDW, MPV, PLR and fibrinogen (p>0.05).

Conclusion: No difference was detected in terms of the presbyacusis, hearing loss types and CBC parameters. According to the study results presbyacusis types and inflammatory mediators did not correlate with each other.

Keywords: presbycusis, geriatric, complete blood count, inflammatory markers, hearing loss

Corresponding Author: Zeynel Abidin Erkan, MD, Department of Otorhinolaryngology and Head and Neck Surgery, Çukurova State Hospital. Address: Süleyman Demirel Bulvarı, Çukurova, Adana, Turkey. Tel.: +905054742707. E-mail:



1. Gates G.A, Mills J.H. Presbycusis. Lancet. 2009; 366:1111-1120. PMID:16182900

2. Sprinzl G.M., Riechelmann H. Current trends in treating hearing loss in elderly people: a review of the technology and treatment options - a mini-review. Gerontology. 2010; 56:351-8. PMID:20090297

3. Tu N.C., Friedman R.A. Age-Related Hearing Loss: Unraveling the Pieces. Laryngoscope Investigative Otolaryngology. 2018; 3(2):68-72. PMID:29721536

4. Kum R.O., Ozcan M., Baklaci D., et al. Investigation of neutrophil-to-lymphocyte ratio and mean platelet volume in sudden hearing loss. Braz J Otorhinolaryngol. 2015; 81:636-41. PMID:26480902

5. Schuknecht H.F., Gacek M.R. Cochlear pathology in presbycusis. Ann Otol Rhinol Laryngol. 1993; 102:1-16. PMID:8420477

6. Watsona N., Dingb B., Zhub X., Frisina R.D. Chronic Inflammation - Inflammaging - in the Ageing Cochlea: A Novel Target for Future Presbycusis Therapy. Ageing Res Rev. 2018; 40: 142-148. PMID:29017893

7. Fulop T., Dupuis G., Witkowski J.M., Larbi A. The Role of Immunosenescence in the Development of Age-Related Diseases. Rev Invest Clin. 2016; 68(2):84-91. PMID:27103044

8. Chung H.Y., Kim H.J., Kim K.W., Choi J.S., Yu B.P. Molecular inflammation hypothesis of aging based on the anti-aging mechanism of calorie restriction. Microsc Res Tech. 2002; 59(4):264-72. PMID:12424787

9. Verschuur C., Agyemang-Prempeh A., Newman T.A. Inflammation is associated with a worsening of presbycusis: evidence from the MRC national study of hearing. Int J Audiol. 2014; 53(7):469-75. PMID:24679110

10. Lowthian J.A., Britt C.J., Rance G., Lin F.R., Woods R.L., Wolfe R., et al. Slowing the progression of age-related hearing loss: Rationale and study design of the ASPIRIN in HEARING, retinal vessels imaging and neurocognition in older generations (ASPREE-HEARING) trial. Contemp Clin Trials. 2016; 46:60-6. PMID:26611434

11. Dabbah S., Hammerman H., Markiewicz W., Aronson D. Relation between red cell distribution width and clinical outcomes after acute myocardial infarction. Am J Cardiol. 2010; 105:312-7. PMID:20102941

12. Wen Y. High red blood cell distribution width is closely associated with risk of carotid artery atherosclerosis in patients with hypertension. Exp Clin Cardiol. 2010; 15:37-40. PMID: 20959889

13. Yasan H., Tüz M., Yariktaş M., Aynali G., Tomruk Ö., Akkus O. The Significance of Routine Laboratory Parameters in Patients with Sudden Sensorineural Hearing Loss. Indian J Otolaryngol Head Neck Surg. 2013; 65(3):553-556. PMID:24427713

14. Ezerarslan H., Basaran M. Hematologic parameters in geriatric patients with idiopathic sudden sensorineural hearing loss. Turkish J Geriatrics. 2016; 19(1):35-41

15. Freeman R.B., Wiesner R.H., Harper A., McDiarmid S.V.,Lake J. The new liver allocation system: moving toward evidence based transplantationpolicy. Liver Transpl.2002; 8:851-58. PMID: 12200791

16. Tuhanioglu B., Erkan S.O., Dınız Z., Gorgulu O., Kuran G. Relationship between severity of obstructive sleep apnea and age and inflammatory mediators in geriatric patients. Turkish J Geriatrics. 2017; 20:271-79

17. Demirkol S., Balta S., Unlu M. et al . Neutrophils/lymphocytes ratio in patients with cardiac syndrome X and its association with carotid intima-media thickness. Clin Appl Thromb Hemost. 2014; 20:250-255. PMID:23188887

18. Ulu S., Bucak A., Ulu M.S., Ahsen A., Duran A., Yucedag F., Aycıcek A. Neutrophil-lymphocite ratio as a new predictive and prognostic factor at the hearing loss of diabetic patients. Eur Arch Otorhinolaryngol. 2014; 271:2681-6. PMID:24121821

19. Gasparyan A.Y., Ayvazyan L., Fau-Mikhailidis D.P., et al. Mean platelet volume: a link between thrombosis and inflammation? Curr Pharm Des. 2011; 17:47-58. PMID:21247392

20. Sagıt M., Kavugudurmaz M., Guler S., Somdas M.A. Impact of mean platelet volume on the occurrence and severity of sudden sensorineural hearing loss. The Journal of Laryngology & Otology. 2013; 127:972-976. PMID:24041223

21. Gary T., Pichler M., Belaj K., et al. Platelet-to-lymphocyte ratio: a novel marker for critical limb ischemia in peripheral arterial occlusive disease patients. Plos One. 2013; 8:e67688. PMID:23844064

22. Sun Y., Guo Y., Wang H., Chen Z., Wu Y., Shi H., Feng Y. et al. Differences in platelet-related parameters among patients with audiographically distinct sudden sensorineural hearing loss: A retrospective study. Medicine. 2017; 96(36):e7877.(PMID:28885341)

23. Christ-Crain M., Müller B. Procalcitonin in bacterial infections-hype, hope, more or less? Swiss Med Wkly. 2005; 135(31-32):451-460. PMID:16208582

24. Yu J., Wang L., Peng Y., Xiong M., Cai X., Luo J., et al. Dynamic Monitoring of Erythrocyte Distribution Width (RDW) and Platelet Distribution Width (PDW) in Treatment of Acute Myocardial Infarction. Med Sci Monit. 2017; 23:5899-5906. PMID:29233957

25. Weisel J.W., Litvinov R.I. Mechanisms of fibrin polymerization and clinical implications. Blood. 2013; 121(10):1712-9. PMID:23305734

26. Salvago P., Rizzo S., Bianco A., Martines F.. Sudden sensorineural hearing loss: is there a relationship between routine haematological parameters and audiogram shapes? Int J Audiol. 2017; 56(3):148-53. PMID:27712131


Көлем (Объем) 3, Сан (Число) 53 (2019)