A comparison of the effectiveness of rosuvastatin, atorvastatin and simvastatin in achieving target lipid levels (according to the PROFILE-I registry)

Сравнение эффективности применения розувастатина, аторвастатина и симвастатина в достижении целевых уровней общего холестерина и липопротеидов низкой плотности (по данным регистра ПРОФИЛЬ-I)
Oleg V Gaisenok 1 2 3
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1 FSI United Hospital with Outpatient department, Moscow, Russia
2 Research Center of Medical forecasting and analysis, Moscow, Russia
3 National Research Сenter of preventive medicine, Moscow, Russia
J CLIN MED KAZ, Volume 4, Issue 46, pp. 20-25. https://doi.org/10.23950/1812-2892-JCMK-00526
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The aim of the study: was to evaluate the effectiveness of lipid-lowering therapy, depending on the choice of statin in patients with cardiovascular disease in a cohort study.
Methods: Data analysis was performed in the Profile-I registry patients. The results of the examination of 148 patients were selected for the final analysis on the basis of the presence of indications for prescribing statins, the availability of data on the choice of statin and the availability of results of lipid spectrum from 274 registry patients.
Results: The values ​​of total cholesterol and LDL-С were significantly lower in the rosuvastatin group than in the atorvastatin and simvastatin groups (respectively 4.3, 4.7 and 4.6 mmol/l, p = 0.03;2.36, 2.98, and 2.66 mmol/l, p = 0.01).
Conclusion: the achievement of more optimal levels of lipid spectrum turned out to be dependent on the choice of statin in this study in favor of rosuvastatin.


Gaisenok OV. A comparison of the effectiveness of rosuvastatin, atorvastatin and simvastatin in achieving target lipid levels (according to the PROFILE-I registry). Journal of Clinical Medicine of Kazakhstan. 2017;4(46):20-5. https://doi.org/10.23950/1812-2892-JCMK-00526


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