A Comparison of Vitamin D Levels in Patients with Acne Vulgaris and Healthy Individuals

Сравнение уровня витамина D у пациентов с обыкновенными угрями и здоровых субъектов
Gülbahar Saraç 1, Tuba Tülay Koca 2, Serpil Şener 1, Hülya Cenk 1
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1 Inonu University, Department of Dermatology, Malatya, Turkey
2 Research and Training Hospital, Physical Medicine and Rehabilitation Clinic, Malatya, Turkey
J CLIN MED KAZ, Volume 2, Issue 44, pp. 33-35. https://doi.org/10.23950/1812-2892-JCMK-00440
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ABSTRACT

Study Objective: It is a common opinion that vitamin D plays a role in many immune system disorders. This study aimed to determine vitamin D levels in patients with acne vulgaris.
Methodology: The study sample included 90 patients who came to the outpatient dermatology clinic of Malatya Public Hospital between March 2015 and June 2015, and were diagnosed with cystic nodular acne clinically. The control group included 67 voluntary healthy individuals. The 25-hydroxyvitamin D3 [25-(OH) vit D3] levels were recorded for both groups.
Findings: In the group of patients with acne, the 25-(OH) vit D3 level was 18.28±9.92 (reference interval 10–40 ng/mL), and it was 15.40±10.92 in the control group. When the two values were compared statistically, the result was p:0.924 (p>0.05) and there was no statistically signifcant difference.
Conclusion: It is believed that vitamin D plays a role in the etiopathogenesis of acne vulgaris due to its anti-inflammatory and antimicrobial properties. The studies conducted with larger patient sets canprovide a clearer view of the correlation between vitamin D and acne.

CITATION

Saraç G, Koca TT, Şener S, Cenk H. A Comparison of Vitamin D Levels in Patients with Acne Vulgaris and Healthy Individuals. Journal of Clinical Medicine of Kazakhstan. 2017;2(44):33-5. https://doi.org/10.23950/1812-2892-JCMK-00440

REFERENCES

  • Layton AM. A review on thetreatment of acnevulgaris. J ClinPract. 2006;60:64-72.
  • Glover TL, Goodin BR, Horgas AL, Kindler LL, King CD, Sibille KT, et al. Vitamin D, race, and experimental pain sensitivity in older adults with knee osteoarthritis. Arthritis Rheum. 2012;64:3926-35.
  • Holick MF. Vitamin D deficiency. N Eng J Med. 2007;357:266-81.
  • Bhambri S, Del Rosso JQ, Bhambri A. Pathogenesis of acne vulgaris: recent advances. J Drugs Dermatol. 2009;8(7):615-8.
  • Nicholson I., Dalzell, A.M. and El-Matary, W. (2012). Vitamin D as a therapy for colitis: a systematic review. Journal of Crohns Colitis, 6(4), 405-411.
  • Myszka M, Klinger M.[The immunomodulatory role of Vitamin D]. Postepy Hig Med Dosw (Online). 2014;68:865-78.
  • Krishnan AV, Feldman D. Mechanisms of the anticancer and anti-inflammatory actions of vitamin D. Annu Rev Pharmacol Toxicol. 2011;51:311-336.
  • Liu PT, Stenger S, LI H, Wenzel L, Tan BH, Krutzik SR, et al. Activation of human TLR 2/1 triggers a vitamin D receptordependent antimicrobial response. Science. 2006; 311:1770-3.
  • Ponsonby AL, McMichael A, van der Mei I. Ultraviolet radiation and autoimmune disease: insights from epidemiological research. Toxicology. 2002; 181182:71-8.
  • Morimoto S, Kumahara Y. A patient with psoriasis cured by 1 alpha-hydroxyVitD3. Med J Osaka Univ. 1985;35:51-4.
  • Parsad D, Saini R, Nagpal R. Calcipotriol in vitiligo: a preliminary study. Pediatr Dermatol. 1999;16:317-20.
  • Cunningham BB, Landells ID, Langman C, Sailer DE, Paller AS. Topical calcipotriene eformorphea/linear scleroderma. J Am Acad Dermatol. 1998;39:211-5. 36.
  • Toossi P, Azizian Z, Yavari H, Fakhim TH, Amini SH, Enamzade Z. Serum 25-hydroxy vitamin D levels in patients with acne vulgaris andits association with disease severity. Clin Cases Miner Bone Metab. 2015;12(3):238-42.
  • Yildizgören MT, Torgal AK. Preliminary evidence for vitamin D deficiency in nodulocystic acne. Dermatol endocrinol. 2015;14:6(1):983687-4.
  • Basak PY, Glutekin F, Kilinc I. The role of the antioxidative defense system in papulopustular acne. J Dermatol. 2001;28:123-7.
  • Bowe WP, Logan AC. Clinical implications of lipid peroxidation in acne vulgaris: old wine in new bottles. Lipids in Health Disease. 2010; 9 [Online]. http://www.lipidworld.com/content/9/1/141.
  • Marashian SM, Farnia P, Seyf Sh, Anoosheh S, Velayati AA. Evaluating the role of vitamin D receptor polymorphisms on susceptibility to tuberculosis among Iranian patients: a case-control study. Tuberkuloz ve Toraks Dergisi. 2010;58(2):147-