A giant Condyloma Acuminata of Buschke and Lowenstein extending to the inguinal area and penis

Гигантская кондилома Бушке-Левенштейна в паховой области и в половом члене
Gafur Khairli 1, Anvar Davranov 2, Akylbek Zhumakayev 1, Yernur Ainayev 1, Ulanbek Balpukov 1, Asset Bolatov 1, Elijah Kehinde 3
More Detail
1 Urology Department, Astana Medical University, Astana, Republic of Kazakhstan
2 Surgery Department, National Scientific Center for Oncology and Transplantation, Astana, Republic of Kazakhstan
3 School of Medicine, Nazarbayev University, Astana, Republic of Kazakhstan
J CLIN MED KAZ, Volume 2, Issue 48, pp. 52-55. https://doi.org/10.23950/1812-2892-JCMK-00546
Download Full Text (PDF)


Objective: Anogenital warts (condyloma acuminatum or veneral warts) are a common sexually transmitted disease among males and females. The causal role of human papilloma virus in anogenital wart formation has been firmly established.
Case presentation: We report a case of a giant condyloma acuminata involving the penis, inguinoscrotal area and extending to the pubic region in a 30-year-old male patient. It was treated by wide surgical excision. Excision defect was extensive and required cover with fascio-cutaneous flap. The postoperative course of the patient was uneventful. Histological examination confirmed giant condyloma acuminata without evidence of malignancy.
Conclusion: While there is no standard treatment for giant condyloma acuminate due to its biological behavior, surgical excision remains the method of choice to achieve local control of the disease. This case report confirms previous observation that extensive giant condyloma acuminate involving the penis or groin areas rarely become malignant compared to that involving the anorectal area of the body.


Khairli G, Davranov A, Zhumakayev A, Ainayev Y, Balpukov U, Bolatov A, et al. A giant Condyloma Acuminata of Buschke and Lowenstein extending to the inguinal area and penis. Journal of Clinical Medicine of Kazakhstan. 2018;2(48):52-5. https://doi.org/10.23950/1812-2892-JCMK-00546


  • Baken L A, Koutsky LA, Kuypers J, et al. Genital human papillomavirus infection among male and female sex partners: prevalence and type-specific concordance. J Infect Dis. 1995;171:429–432.
  • Patel H., Wagner M., Singhal P., Kothari S. Systematic review of the incidence and prevalence of genital warts. BMC Infectious Diseases. 2013;13:1471-1479.
  • Attipou K, Yawovi K, James N, Napo-Koura GA, Tchangaï-Walla A, James K. Giant anal condyloma acuminatum in childhood: A case report. Nig. J. Surg. Res. 2001; 3: 170–4.
  • Li AL, Walsh S, McKay DR. Surgical management of a giant condyloma of Buschke-Löwenstein in a patient with Netherton syndrome using the pedicled anterolateral thigh flap – a case report. J Plast Reconstr Aesthet Surg. 2011;64: 1533-6.
  • Tytherleigh MG, Birtle AJ, Cohen CE, Glynne-Jones R, Livingstone J, et al. Combined surgery and chemoradiation as a treatment for the Buschke-Lowenstein tumor. Surgeon 2006; 4: 378-383.
  • A. Kreuter A, Potthoff NH, Brockmeyer P et al, Anal carcinoma in human immunodeficiency virus-positive men: results of a prospective study from Germany. Brit J Dermatol 2010;162:1269–1277.
  • Creasman C, Haas PA, Fox TA Jr, Balazs M. Malignant transformation of anorectal giant condyloma acuminatum (BusckeLoewenstein tumor). Dis Colon Rectum 1989; 32: 481- 487.
  • Bertram P, Treutner KH, Rubben A, et al. Invasive squamous-cell carcinoma in giant anorectal condyloma (Buscke-Loewenstein tumor). Langenbecks Arch Chir 1995; 380: 115-118.
  • Koutsky LE. Epidemiology of genital human papiloma virus infection. Am J Med.1997:102:3—8.
  • Creasman C, Haas PA, Fox TA Jr, Balazs M. Malignant transformation of anorectal giant condyloma acuminatum (BuschkeLoewenstein tumor) Dis Colon Rectum. 1989;32:481–487.
  • Chu QD, Vezeridis MP, Libbey NP, Wanebo HJ. Giant condyloma acuminatum (Buschke-Lowenstein tumor) of the anorectal and perianal regions. Analysis of 42 cases. Dis Colon Rectum Sep 1994; 37: 950-957.
  • Reichenbach I, Koebell A, Foliguet B, Hatier M, Mascotti J, Landes P. Tumeur de Buschke et Lowenstein à propos d’un cas feminin. J Gynecol Obstet Biol Reprod 1995; 24: 491-495.
  • Noorwood Ch, Mather MK. Giant Condylomata Acuminata of Buschke and Lowenstein [Consultado el 15 de agosto del 2013]
  • Parise P, Sarzo G, Finco C, Marino F, Savastano S, Merigliano S. Giant condyloma acuminatum of the anorectum (BuschkeLowenstein tumor): A case report of conservative surgery. Chir Ital 2004; 56: 157-161.
  • Mestrovic T, Cavcic J, Martinac P,Turcic, Zupancic B, Cavcic AM, Jelincic Z. Reconstruction of skin defects after radical excision of anorectal giant condyloma acuminatum: 6 cases. JEADV 2003; 17: 541-545.
  • Nahai F, Hill HL, Hister TR. Experiences with the tensor fascia lata flap. Plast. Reconstr. Surg.,1979; 63:788-785
  • Bostwick J, Hill HL, Nahai F. Repair of large soft tissue defects of inguinal region and perineum with myocutaneous or omental flaps. Plast. Reconstr. Surg.1979; 63: 186.
  • Wang T, Whetzel T, Mathes SJ, Vasconez LO. Fasciocutaneous flap for vaginal and perineal reconstruction. Plast. Reconstr. Surg., 1987; 80: 95-102.