Aminotransferases activity on additional therapy in rheumatoid arthritis patients with liver disease.

Iryna Klymas 1 * , Liudmyla Khimion 1
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1 Department of Internal Diseases, Family Medicine, Hematology and Transfusiology, Shupyk National Healthcare University of Ukraine, Kyiv, Ukraine
* Corresponding Author
J CLIN MED KAZ, Volume 21, Issue 2, pp. 89-94.
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Author Contributions: Conceptualization, I.K. and L.K.; methodology, I.K. and L.K.; validation, I.K. and L.K.; formal analysis, I.K. and L.K.; investigation, I.K. and L.K.; data curation, I.K. and L.K.; writing – original draft preparation, I.K. and L.K.;  writing – review and editing, I.K. and L.K.;  visualization, K.H.S.; supervision, I.K. and L.K. All authors have read and agreed to the published version of the manuscript.


Aim. Investigate the effect of additional therapy of atorvastatin, essential phospholipids and their combination on activity of aminotransferases in RA patients with NAFLD.
Materials and Methods. We investigated 126 RA patients and 30 in control. 77 RA patients with NAFLD were divided into three groups. I: 25 RA patients received 10 mg of atorvastatin per day. II: 26 RA patients received essential phospholipids 1800 mg per day. III: 26 RA patients received essential phospholipids 1800 mg per day and atorvastatin 10 mg per day for 6 months.
The results. In the I group, a transient increase in ALT and AST activity was observed to 35.11±3.501 U/l and 30.51±2.19 U/l, respectively, and a spontaneous decrease in elevated transaminases was recorded after 6 months of atorvastatin use. In the II group, a decrease in ALT by 25.6% was observed compared to the indicators before treatment, and they remained unchanged even after 6 months. After 3 months of complex use of atorvastatin and essential phospholipids, ALT activity decreased by 33.8% and AST decreased by 8.2%, which was not observed in RA patients with NAFLD of groups I and II.
Conclusions. Use essential phospholipids 600 mg three times a day and atorvastatin 10 mg per day for 6 months in addition to antirheumatic therapy in RA patients with NAFLD allows to avoid a transient increase in aminotransferases, reduce the severity of hepatotoxic reactions, and avoid stopping or canceling antirheumatic therapy.


Klymas I, Khimion L. Aminotransferases activity on additional therapy in rheumatoid arthritis patients with liver disease.. J CLIN MED KAZ. 2024;21(2):89-94.


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