Aspirin Intolerance in the Setting of Acute Coronary Syndrome: Case Report and Review of Literature
Temirbek Janpaizov 1 * ,
Ilvira Ibraimova 2,
Erlan Zhumagulov 1,
Kaisar Dauyey 2 More Detail
1 Department of Interventional Cardiology and Arrhythmology, City Multidisciplinary Hospital No. 2, Astana, Kazakhstan
2 Department of Medicine, School of Medicine, Nazarbayev University, Astana, Kazakhstan
* Corresponding Author
J CLIN MED KAZ, Volume 22, Issue 2, pp. 61-63.
https://doi.org/10.23950/jcmk/16252
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Author Contributions: Conceptualization, T. J.; methodology, I. I. and T. J.; validation, T. J., E. Z.; formal analysis, T.J.; investigation, T. J., E. Z. and I. I.; resources, T. J.; data curation, E. Z.; writing – original draft preparation, T. J., I. I. and K. D.; writing – review and editing, I. I. and K. D.; visualization, K. D.; supervision, I. I.; project administration, T. J.; funding acquisition, T. J. All authors have read and agreed to the published version of the manuscript.
Informed Consent: We received the written informed consent from the patient for the publication of this case report, along with the associated medical imaging. A copy of the written informed consent is available upon request from the corresponding author.
Ethics approval: The medical imaging lacks identifiable information; all personal details are excluded from the text. All authors accept responsibility for this publication's content and any related inquiries.
ABSTRACT
Acute coronary syndrome (ACS) requires prompt intervention to prevent myocardial ischemia. This case report describes a patient’s clinical journey, highlighting the challenges associated with aspirin intolerance and the necessity of an alternative antithrombotic approach. The patient, who presented with ACS and a documented history of aspirin-induced asthma and angioedema, was unable to undergo standard dual antiplatelet therapy (DAPT) with aspirin. Given the urgency of intervention and failed prior aspirin desensitization, ticagrelor and rivaroxaban were selected as alternative agents. The patient underwent successful percutaneous coronary intervention (PCI) with stent placement and was managed postoperatively using a modified antithrombotic regimen. The case underscores the importance of individualized therapy in aspirin-intolerant ACS patients and suggests a viable alternative strategy for anticoagulation and platelet inhibition. Patient outcomes were favorable, demonstrating effective ischemic risk mitigation without aspirin-related hypersensitivity reactions.
CITATION
Janpaizov T, Ibraimova I, Zhumagulov E, Dauyey K. Aspirin Intolerance in the Setting of Acute Coronary Syndrome: Case Report and Review of Literature. J CLIN MED KAZ. 2025;22(2):61-3.
https://doi.org/10.23950/jcmk/16252
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