Assessment of antibacterial and antifungal activity of a biocomposite based on nanocellulose in vitro
Madina Rashova 1 * ,
Zhanerke Amirkhanova 2,
Saule Akhmetova 3,
Berik Tuleubaev 4,
Dinara Turebekova 5,
Amina Koshanova 6,
Vladimir Vinokurov 7 More Detail
1 PhD student of the Karaganda Medical University, Karaganda, Gogol Street 40, Kazakhstan.
2 Associate Professor, Department of Biomedicine, "Karaganda Medical University", Karaganda, Gogol Street 40
3 Professor, Department of Biomedicine, "Karaganda Medical University", Karaganda, Gogol Street 40
4 Head of the Department of Surgical Diseases, "Karaganda Medical University", Karaganda, Gogol Street 40
5 . Junior Researcher, Research Laboratory, Institute of Life Sciences, "Karaganda Medical University", Karaganda, Gogol Street 40
6 Associate Professor, Department of Surgical Diseases, "Karaganda Medical University", Karaganda, Gogol Street 40,
7 Head of Department of Physical and Colloid Chemistry, Doctor of Chemical Sciences, Professor of the Federal State Autonomous Educational Institution of Higher Education “Gubkin Russian State University of Oil and Gas (National Research University)”, Moscow
* Corresponding Author
J CLIN MED KAZ, In press.
OPEN ACCESS
96 Views
0 Downloads
ABSTRACT
Abstract
Relevance
Biomaterials which used in the treatment of osteomyelitis, should not only fill in bone defects, but also be a “tool” for local delivery of antibiotics. The bone substitute is the biomaterial of human, animal, plant or synthetic genesis, implanted into the body to restore and strengthen bone substance. The creation of the latest nanocompositional materials today is the main direction of the development of science and technology. Nanocellulose (NC) and biocomposits based on it became one of the most promising “green” materials due to its unique properties.
Materials and methods
For preclinical testing, three samples of the NC were provided: nanofibrillar, nanocritic, microfibrillar nanocellulose. The microbiological purity was studied, the minimum-inhibitory concentration of the antibiotic, and the study of the antibacterial and antifungicide effect of biocomposite samples by the method of museum tests of Staphylococcus aureus (ATCC 6538), Escherichia coli (ATCC 25922), Bacillus subtilis (ATCC 6633), Candida Albicans ( ATCC 10231)
by measuring the diameter of the growth retardation zone.
Results
Biocomposites based on nanocellulose, saturated with antibiotics, demonstrate high antibacterial and antifungicidal potential. Further experimental studies are required by their ability to uniform and slow controlled release of the active substance, along with the effective suppression of the growth of microorganisms and a prolonged effect, which would allow them to be considered as an effective local transport system.
CITATION
Rashova M, Amirkhanova Z, Akhmetova S, Tuleubaev B, Turebekova D, Koshanova A, et al. Assessment of antibacterial and antifungal activity of a biocomposite based on nanocellulose in vitro. J Clin Med Kaz. 2025.