Association of gene polymorphism at atrial fibrillation: A literature review

Dana Taizhanova 1, Nazira Bazarova 1, Elena Zholdybayeva 2, Akerke Kalimbetova 1 *
More Detail
1 Department of Internal Diseases, NC JSC Medical University of Karaganda, Karaganda, Kazakhstan
2 National Scientific Shared Laboratory of Biotechnology, National Center of Biotechnology, Nur-Sultan, Kazakhstan
* Corresponding Author
J CLIN MED KAZ, Volume 18, Issue 1, pp. 19-22. https://doi.org/10.23950/jcmk/9666
OPEN ACCESS
Download Full Text (PDF)

ABSTRACT

Atrial fibrillation (AF) is the most common persistent heart rhythm disorder, the prevalence of which increases with age. The progressive prevalence of AF is becoming a serious threat to public health throughout the world, as it is associated with high mortality rates. In the review, we analyzed the literature data on the state of knowledge of the genetic nature of AF. To achieve this goal, a systematic search and subsequent analysis of publications and online resources was carried out. All publications are indexed in PubMed, Medline, e-library, Coogle Scholar. To date, at least 30 loci associated with AF have been identified. At the same time, the research results depend on such factors as ethnicity, concomitant cardiac and extracardiac diseases, inheritance mechanisms, and intergenic interactions. The complexity of etiopathogenesis, the heterogeneity of AF poses the task of researchers to further search for factors that play a leading role in the development of the disease. Significant progress in understanding the genetic basis of AF was achieved with the advent of large-scale genomic GWAS studies, which include genotyping up to a million common variants or single nucleotide polymorphisms. The currently available data on the association of candidate genes with AF in case-control studies are controversial and necessitate more detailed studies on various ethnic groups.

CITATION

Taizhanova D, Bazarova N, Zholdybayeva E, Kalimbetova A. Association of gene polymorphism at atrial fibrillation: A literature review. J CLIN MED KAZ. 2021;18(1):19-22. https://doi.org/10.23950/jcmk/9666

REFERENCES

  • Benjamin, Emelia J et al. Heart Disease and Stroke Statistics-2019 Update: A Report From the American Heart Association. Circulation. 2019; 139(10:e56-e528. doi:10.1161/CIR.0000000000000659.
  • Chugh, Sumeet S., et al. "Worldwide epidemiology of atrial fibrillation: a Global Burden of Disease 2010 Study." Circulation. 2014; 129(8):837-847. doi: 10.1161 / CIRCULATIONAHA.113.005119
  • Kolbin A. S., Mosikyan A. A., Tatarskiy B. A. Socio-economic burden of atrial fibrillation in Russia: dynamics for 7 years (2010-2017). Bulletin of arrhythmology. 2018; 92:42-48.
  • Akpanova D. M. et al. Prevalence and general risk factors for the development of atrial fibrillation. Bulletin of the Kazakh National Medical University. 2016; 2:70-75.
  • Andersson, Tommy, et al. All-cause mortality in 272 186 patients hospitalized with incident atrial fibrillation 1995–2008: a Swedish nationwide long-term case–control study. European heart journal. 2013; 34(14):1061-1067. https://doi.org/10.1093/eurheartj/ehs469
  • Fisher, Marc, Joseph A. Hill. Ischemic stroke mandates cross-disciplinary collaboration. (2018):103-105. https://doi.org/10.1161/CIRCULATIONAHA.117.032903
  • Suslov A. S. Assessment of the nosological affiliation of atrial fibrillation in real clinical practice. Practical medicine. 2014; 6(82):114-117.
  • Trigub A. V. Clinical characteristics of patients with various forms of atrial fibrillation. Innovations in medicine. 2017; 144-148.
  • Soloviyov O. V., Lukyanova I. Yu. Clinical conditions associated with atrial fibrillation not associated with valvular heart disease. Juvenis Scientia. 2019; 7:8-13.
  • January, Craig T., et al. 2014 AHA/ACC/HRS guideline for the management of patients with atrial fibrillation: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and the Heart Rhythm Society. Journal of the American College of Cardiology. 2014; 64(21):e1-e76.
  • Marcus, Gregory M., et al. A first-degree family history in lone atrial fibrillation patients. Heart Rhythm. 2008; 5(6):826-830. https://doi.org/10.1016/j.hrthm.2008.02.016
  • Ellinor, Patrick T., et al. Familial aggregation in lone atrial fibrillation. Human genetics. 2005; 118(2):179-184. DOI: 10.1007/s00439-005-0034-8
  • Chen, Lin Y., et al. Lone atrial fibrillation: influence of familial disease on gender predilection. Journal of cardiovascular electrophysiology. 2008; 19.8:802-806. https://doi.org/10.1111/j.1540-8167.2008.01126.x
  • Anumonwo, Justus MB, and Jérôme Kalifa. Risk factors and genetics of atrial fibrillation. Heart failure clinics. 2016; 12(2):157-166. DOI:https://doi.org/10.1016/j.hfc.2015.08.013
  • Mahida, Saagar, et al. Monogenic atrial fibrillation as pathophysiological paradigms. Cardiovascular research. 2011; 89(4):692-700. https://doi.org/10.1093/cvr/cvq381
  • Fatkin, Diane, et al. Genetics of atrial fibrillation: state of the art in 2017. Heart, Lung and Circulation. 2017; 26(9):894-901. https://doi.org/10.1016/j.hlc.2017.04.008
  • Chalazan, Brandon, et al. Genetic modulation of atrial fibrillation risk in a Hispanic/Latino cohort. PloS one. 2018; 13(4):e0194480. https://doi.org/10.1371/journal.pone.0194480
  • А. В. Kuskayeva, S. Yu. Nikulina, A. A. Chernova, N. V. Aksyutina. Genetic predictors of atrial fibrillation. Ration. pharmacotherapy in cardiology. 2016; 12(3):331-336. https://doi.org/10.20996/1819-6446-2016-12-3-331-336
  • Mahida, Saagar. Genetic discoveries in atrial fibrillation and implications for clinical practice. Arrhythmia & electrophysiology review. 2014; 3.2:69-75 doi: 10.15420/aer.2014.3.2.69
  • Topal, Nurdan Papila, et al. Polymorphisms of the angiotensin-converting enzyme and angiotensinogen gene in patients with atrial fibrillation. Journal of the Renin-Angiotensin-Aldosterone System. 2011; 12(4): 549-556. https://doi.org/10.1177/1470320311399605
  • Ma, Runwei, et al. Angiotensin-converting enzyme insertion/deletion gene polymorphisms associated with risk of atrial fibrillation: A meta-analysis of 23 case-control studies. Journal of the Renin-Angiotensin-Aldosterone System. 2015; 16(4):793-800. https://doi.org/10.1177/1470320315587179
  • Wang, Qun-shan, et al. Angiotensinogen polymorphisms and acquired atrial fibrillation in Chinese. Journal of Electrocardiology. 2010; 43(4):373-377. https://doi.org/10.1016/j.jelectrocard.2009.09.009
  • Wang, HuiXuan, et al. The M235T polymorphism in the angiotensinogen gene and atrial fibrillation: A meta-analysis. Journal of the Renin-Angiotensin-Aldosterone System. 2015; 16.3:647-652. https://doi.org/10.1177/1470320313513482
  • Chalazan, Brandon, et al. Genetic modulation of atrial fibrillation risk in a Hispanic/Latino cohort. PloS one. 2018; 13(4):e0194480. https://doi.org/10.1371/journal.pone.0194480
  • Nakano, Yukiko, et al. HCN4 gene polymorphisms are associated with occurrence of tachycardia-induced cardiomyopathy in patients with atrial fibrillation. Circulation: Genomic and Precision Medicine. 2018; 11(7):e001980. https://doi.org/10.1161/CIRCGEN.117.001980
  • Wang, Xiaoxu, Yingzheng Li, and Qiulai Li. A comprehensive meta-analysis on relationship between CYP11B2 rs1799998 polymorphism and atrial fibrillation. Journal of Electrocardiology. 2019; 52:101-105. https://doi.org/10.1016/j.jelectrocard.2018.11.009
  • Manolio, Teri A. Genomewide association studies and assessment of the risk of disease. New England journal of medicine. 2010; 363(2):166-176. DOI: 10.1056/NEJMra0905980
  • Gudbjartsson D.F., Arnar D.O., Helgadottir A., Gretarsdottir S., Holm H., Sigurdsson A. et al. Variants conferring risk of atrial fibrillation on chromosome 4q25. Nature. 2007; 448(7151):353–7. DOI: 10.1038/nature06007
  • Benjamin, Emelia J., et al. Variants in ZFHX3 are associated with atrial fibrillation in individuals of European ancestry. Nature genetics. 2009; 41(8):879-881. DOI: 10.1038/ng.416
  • Ellinor, Patrick T., et al. Common variants in KCNN3 are associated with lone atrial fibrillation. Nature genetics. 2010; 42(3):240-244. DOI: 10.1038/ng.537
  • Ellinor P.T., Lunetta K.L., Albert C.M., Glazer N.L., Ritchie M.D., Smith A.V. et al. Meta-analysis identifies six new susceptibility loci for atrial fibrillation. Nat. Genet. 2012; 44(6):670–5. DOI: 10.1038/ng.2261
  • Olesen, Morten S., et al. Atrial fibrillation: the role of common and rare genetic variants. European Journal of Human Genetics. 2014; 22(3):297-306. https://doi.org/10.1038/ejhg.2013.139
  • Sinner, Moritz F., et al. Integrating genetic, transcriptional, and functional analyses to identify 5 novel genes for atrial fibrillation. Circulation. 2014; 130(15):1225-1235. https://doi.org/10.1161/CIRCULATIONAHA.114.009892
  • Huang, Henry, and Dawood Darbar. Genetic heterogeneity of atrial fibrillation susceptibility loci across racial or ethnic groups. 2017; 2595-2598. https://doi.org/10.1093/eurheartj/ehx289
  • Roselli C. et al. A multi-ethnic study of the genomic association for atrial fibrillation. Nature Genetics. 50(9):1225-1233. https://doi.org/10.1038/s41588-018-0133-9
  • Huang, Henry, Dawood Darbar. Genetic heterogeneity of atrial fibrillation susceptibility loci across racial or ethnic groups. 2017; 2595-2598. https://doi.org/10.1093/eurheartj/ehx289
  • Szirák, Krisztina, et al. PITX2 and NEURL1 SNP polymorphisms in Hungarian atrial fibrillation patients determined by quantitative real-time PCR and melting curve analysis. Journal of biotechnology. 2019; 299:44-49. https://doi.org/10.1016/j.jbiotec.2019.04.022
  • Kotecha, Dipak, et al. Integrating new approaches to atrial fibrillation management: the 6th AFNET/EHRA Consensus Conference. Ep Europace. 2018; 20(3):395-407. https://doi.org/10.1093/europace/eux318
  • Kirchhof, Paulus, et al. ESC recommendations for the treatment of patients with atrial fibrillation, developed in conjunction with EACTS. Russ J Cardiol. 2017; 7(147):7–86 http://dx.doi.org/10.15829/1560-4071-2017-7-7-86.
  • Colilla, Susan, et al. Estimates of current and future incidence and prevalence of atrial fibrillation in the US adult population. The American journal of cardiology. 2013; 112(8):1142-1147. https://doi.org/10.1016/j.amjcard.2013.05.063