Contrast-Induced Kidney Injury Prediction in STEMI Patients Post-Coronary Intervention

Eldar B. Saparov 1 * , Aruna S. Saparova 2, Miras M. Mugazov 3
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1 Doctoral student, Department emergency medicine, anesthesiology and resuscitation, NAO "Karaganda Medical University", Karaganda, Kazakhstan
2 Trainer of the Center of Practical Skills, NAO "Karaganda Medical University", Karaganda, Kazakhstan
3 Department of Emergency Medicine, Anesthesiology and Resuscitation NAO "Karaganda Medical University", Karaganda, Kazakhstan
* Corresponding Author
J CLIN MED KAZ, Volume 22, Issue 3, pp. 79-83. https://doi.org/10.23950/jcmk/16450
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Author Contributions: Conceptualization, M. M. M.; methodology, M. M. M.; resources, – not applicable; writing – original draft preparation, E. B. S.; writing – review and editing, A. S. S.; project administration, M. M. M.; funding acquisition – not applicable. All authors have read and agreed to the published version of the manuscript.

Data availability statement: The corresponding author can provide the data supporting the study's conclusions upon request. Due to ethical and privacy constraints, the data are not publicly accessible.

ABSTRACT

Abstract
Introduction: Contrast-induced acute kidney injury (CI-AKI) is a significant complication following percutaneous coronary intervention (PCI) in patients with ST-elevation myocardial infarction (STEMI). This study aims to develop a predictive model for CI-AKI using clinical and laboratory data.
Methods: A retrospective cohort study analyzed 63 STEMI patients undergoing PCI between November 2024 and March 2025. Data included demographics, clinical parameters, and pre- and post-intervention laboratory markers. CI-AKI was defined as a ≥25% increase in serum creatinine within 48 hours post-PCI. Logistic regression and R software (version 4.3.1) were used for statistical analysis and modeling, with performance assessed via AUC-ROC.
Results: CI-AKI occurred in 19% of patients (12/63). Key predictors were age (OR 1.06, p=0.03), baseline creatinine (OR 1.82, p=0.01), and contrast dose (OR 1.01, p=0.04). The model achieved an AUC-ROC of 0.82 (95% CI: 0.70-0.93). CI-AKI patients had higher baseline creatinine (103.5 vs. 85.2 µmol/L, p=0.02) and older age (68.4 vs. 61.2 years, p=0.04).
Conclusion: The model effectively predicts CI-AKI risk in STEMI patients post-PCI, highlighting age, creatinine, and contrast dose as critical factors. Prospective validation is needed.
Keywords: Contrast-induced kidney injury, STEMI, percutaneous coronary intervention, predictive modeling, creatinine
Keywords: Contrast-induced kidney injury, STEMI, percutaneous coronary intervention, predictive modeling, creatinine

CITATION

Saparov EB, Saparova AS, Mugazov MM. Contrast-Induced Kidney Injury Prediction in STEMI Patients Post-Coronary Intervention. J CLIN MED KAZ. 2025;22(3):79-83. https://doi.org/10.23950/jcmk/16450

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