Diagnostic significance of hematological parameters in brucellosis

Mehmet Çelik 1 * , Mehmet Reşat Ceylan 1, Deniz Altındağ 2, Nevin Güler Dinçer 3, Sevil Alkan 4
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1 Department of Infectious Diseases, Faculty of Medicine, University of Harran, Şanlıurfa, Turkey
2 Cizre Dr. Selahattin Cizrelioğlu State Hospital, Infectious Disease Clinic, Şırnak, Turkey
3 Department of Statistics, Faculty of Science, University of Mugla Sıtkı Koçman, Muğla, Turkey
4 Department of Infectious Diseases, Canakkale Onsekiz Mart University Faculty of Medicine, Canakkale, Turkey
* Corresponding Author
J CLIN MED KAZ, Volume 20, Issue 1, pp. 50-55. https://doi.org/10.23950/jcmk/12929
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Introduction: Changes in hematological parameters are frequently observed in brucellosis patients. In this study, it was aimed to evaluate the diagnostic significance of some hematological parameters in patients with brucellosis.
Material and methods: In this case-control study, the data of brucellosis patients and healthy volunteers followed up in the Outpatient Clinic of Infectious Diseases between 2018 and 2020 were retrospectively examined. In the hemogram examination of patients with brucellosis and health volunteers; hematological parameters such as the leukocyte, hemoglobin, neutrophil, lymphocyte, monocyte, platelet, ratio of neutrophil/lymphocyte, ratio of platelet/lymphocyte, ratio of monocyte/lymphocyte and mean platelet volume were compared.
Results: 255 people, 169 (66.3%) of whom were diagnosed with brucellosis and 86 (33.7%) from the control group, were included to the study. These participants of 112 (43.9%) were male and 143 (56.1%) were female. The patients diagnosed with brucellosis, of 62 (36.7%) were considered acute, of 62 (36.7%) subacute, and of 45 (26.6%) chronic brucellosis. leukocyte, hemoglobin, neutrophil, and neutrophil/lymphocyte levels were found to be lower in the brucellosis group compared to the control group, while mean platelet volume level was found to be higher. Hemoglobin was found to be lower and mean platelet volume higher in all brucellosis subgroups.
Conclusion: In this study, the following findings were determined to be important: the lowness of leucocyte and hemoglobin and highness of mean platelet volume in brucellosis patients, as well as the highness of lymphocyte levels and lowness of neutrophil/lymphocyte and platelet/lymphocyte levels in the subacute brucellosis subgroup. In addition, it was concluded that the mean platelet volume parameter can be used as a diagnostic test for brucellosis.


Çelik M, Ceylan MR, Altındağ D, Dinçer NG, Alkan S. Diagnostic significance of hematological parameters in brucellosis. J CLIN MED KAZ. 2023;20(1):50-5. https://doi.org/10.23950/jcmk/12929


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