Diagnostic significance of hematological parameters in brucellosis

Mehmet Çelik 1 * , Mehmet Reşat Ceylan 1, Deniz Altındağ 2, Nevin Güler Dinçer 3, Sevil Alkan 4
More Detail
1 Department of Infectious Diseases, Faculty of Medicine, University of Harran, Şanlıurfa, Turkey
2 Cizre Dr. Selahattin Cizrelioğlu State Hospital, Infectious Disease Clinic, Şırnak, Turkey
3 Department of Statistics, Faculty of Science, University of Mugla Sıtkı Koçman, Muğla, Turkey
4 Department of Infectious Diseases, Canakkale Onsekiz Mart University Faculty of Medicine, Canakkale, Turkey
* Corresponding Author
J CLIN MED KAZ, Volume 20, Issue 1, pp. 50-55. https://doi.org/10.23950/jcmk/12929
OPEN ACCESS 647 Views 377 Downloads
Download Full Text (PDF)

ABSTRACT

Introduction: Changes in hematological parameters are frequently observed in brucellosis patients. In this study, it was aimed to evaluate the diagnostic significance of some hematological parameters in patients with brucellosis.
Material and methods: In this case-control study, the data of brucellosis patients and healthy volunteers followed up in the Outpatient Clinic of Infectious Diseases between 2018 and 2020 were retrospectively examined. In the hemogram examination of patients with brucellosis and health volunteers; hematological parameters such as the leukocyte, hemoglobin, neutrophil, lymphocyte, monocyte, platelet, ratio of neutrophil/lymphocyte, ratio of platelet/lymphocyte, ratio of monocyte/lymphocyte and mean platelet volume were compared.
Results: 255 people, 169 (66.3%) of whom were diagnosed with brucellosis and 86 (33.7%) from the control group, were included to the study. These participants of 112 (43.9%) were male and 143 (56.1%) were female. The patients diagnosed with brucellosis, of 62 (36.7%) were considered acute, of 62 (36.7%) subacute, and of 45 (26.6%) chronic brucellosis. leukocyte, hemoglobin, neutrophil, and neutrophil/lymphocyte levels were found to be lower in the brucellosis group compared to the control group, while mean platelet volume level was found to be higher. Hemoglobin was found to be lower and mean platelet volume higher in all brucellosis subgroups.
Conclusion: In this study, the following findings were determined to be important: the lowness of leucocyte and hemoglobin and highness of mean platelet volume in brucellosis patients, as well as the highness of lymphocyte levels and lowness of neutrophil/lymphocyte and platelet/lymphocyte levels in the subacute brucellosis subgroup. In addition, it was concluded that the mean platelet volume parameter can be used as a diagnostic test for brucellosis.

CITATION

Çelik M, Ceylan MR, Altındağ D, Dinçer NG, Alkan S. Diagnostic significance of hematological parameters in brucellosis. J CLIN MED KAZ. 2023;20(1):50-5. https://doi.org/10.23950/jcmk/12929

REFERENCES

  • Bagheri Nejad R, Krecek RC, Khalaf OH, Hailat N, Arenas-Gamboa AM. Brucellosis in the Middle East: Current situation and a pathway forward. PLoS Negl Trop Dis. 2020;14(5):e0008071. https://doi.org/10.1371/journal.pntd.0008071
  • Dadar M, Shahali Y, Whatmore AM. Human brucellosis caused by raw dairy products: A review on the occurrence, major risk factors and prevention. Int J Food Microbiol. 2019;292:39-47. https://doi.org/10.1016/j.ijfoodmicro.2018.12.009
  • Buzgan T, Karahocagil MK, Irmak H, Baran AI, Karsen H, Evirgen O, Akdeniz H. Clinical manifestations and complications in 1028 cases of brucellosis: a retrospective evaluation and review of the literature. Int J Infect Dis. 2010;14(6):e469-e478. https://doi:10.1016/j.ijid.2009.06.031
  • Moosazadeh M, Nikaeen R, Abedi G, Kheradmand M, Safiri S. Epidemiological and Clinical Features of People with Malta Fever in Iran: A Systematic Review and Meta-Analysis. Osong Public Health Res Perspect. 2016;7(3):157-167. https://doi.org/10.1016/j.phrp.2016.04.009
  • Zheng R, Xie S, Lu X, Sun L, Zhou Y, Zhang Y, Wang K. A Systematic Review and Meta-Analysis of Epidemiology and Clinical Manifestations of Human Brucellosis in China. Biomed Res Int. 2018;2018:5712920. https://doi.org/10.1155/2018/5712920
  • Akya A, Bozorgomid A, Ghadiri K, Ahmadi M, Elahi A, Mozafari H, Almasi A, et al. Usefulness of Blood Parameters for Preliminary Diagnosis of Brucellosis. J Blood Med. 2020;11:107-113. https://doi:10.2147/JBM.S245513
  • Yagupsky P, Morata P, Colmenero JD. Laboratory Diagnosis of Human Brucellosis. Clin Microbiol Rev. 2019;33(1):e00073-19. https://doi.org/10.1128/CMR.00073-19
  • Özlü C. Brucellosis From Hematology Perspective. Dental and Medical Journal - Review. 2022;4(1):72-78.
  • El-Koumi MA, Afify M, Al-Zahrani SH. A prospective study of brucellosis in children: relative frequency of pancytopenia. Iran J Pediatr. 2014;24(2):155-160. PMID: 25535533; PMCID: PMC4268834.
  • Markanday A. Acute phase reactants in infections: evidence-based review and a guide for clinicians. Open Forum Infect Dis. 2015;2(3):ofv098. https://doi.org/10.1093/ofid/ofv098
  • Akya A, Rostami-Far Z, Lorestani RC, Khazaei S, Elahi A, Rostamian M, Ghadiri K. Platelet indices as useful indicators of urinary tract infection. Iran J Ped Hematol Oncol. 2019;9(3):159-165. https://doi.org/10.18502/ijpho.v9i3.1165
  • Afyon M, Artuk C. Could mean platelet volume be a useful marker for infectious diseases? a review of literature. Medicine Science. 2016;5(4):1059-1062. https://doi.org/10.5455/medscience.2016.05.8460
  • Balın ŞÖ, Tartar AS, Akbulut A. The predictive role of haematological parameters in the diagnosis of osteoarticular brucellosis. Afr Health Sci. 2018;18(4):988-994. https://doi.org/10.4314/ahs.v18i4.19
  • Mirsaeidi M, Peyrani P, Aliberti S, Filardo G, Bordon J, Blasi F, Ramirez JA. Thrombocytopenia and thrombocytosis at time of hospitalization predict mortality in patients with community-acquired pneumonia. Chest. 2010;137(2):416-420. https://doi.org/10.1378/chest.09-0998
  • Zareifar S, Farahmand Far MR, Golfeshan F, Cohan N. Changes in platelet count and mean platelet volume during infectious and inflammatory disease and their correlation with ESR and CRP. J Clin Lab Anal. 2014;28(3):245-248. https://doi.org/10.1002/jcla.21673
  • Enginar AU, Kacar C. Neutrophil-lymphocyte and platelet-lymphocyte rate and their seasonal differences in ankylosing spondylitis and rheumatoid arthritis patients using anti-TNF medication. Bratisl Lek Listy. 2019;120(8):586-592. https://doi.org/10.4149/BLL_2019_096
  • Jimeno S, Ventura PS, Castellano JM, García-Adasme SI, Miranda M, Touza P, López‐Escobar A. Prognostic implications of neutrophil-lymphocyte ratio in COVID-19. Eur J Clin Invest. 2021;51(1):e13404. https://doi.org/10.1111/eci.13404
  • Olt S, Ergenç H, Açıkgöz SB. Predictive contribution of neutrophil/lymphocyte ratio in diagnosis of brucellosis. Biomed Res Int. 2015;2015:210502. https://doi.org/10.1155/2015/210502
  • Sen P, Demirdal T, Nemli SA. Predictive Value of Inflammation Markers in Brucellosis. Arch Iran Med. 2019;22(11):640-645. https://doi.org/10.4103/ijccm.IJCCM_308_18
  • Bozdemir ŞE, Altıntop YA, Uytun S, Aslaner H, Torun YA. Diagnostic role of mean platelet volume and neutrophil to lymphocyte ratio in childhood brucellosis. Korean J Intern Med. 2017;32(6):1075-1081. https://doi.org/10.3904/kjim.2016.092
  • Parlak E, Alay H, Kesmez Can F, Parlak M, Koşan Z. An evaluation of mean platelet volume, sedimentation, and crp in brucellosis patients. Turk Clin Lab. 2019;10(4):479-483. https://doi.org/10.18663/tjcl.476643
  • Bozkurt F, Aslan E, Deveci Ö, Tekin R. Evaluation of Mean Platelet Volume Levels In Patients With Brucellosis. Anatol J Clin Investig. 2014;8(3):126-129.
  • Kader C, Yolcu S, Erbay A. Evaluation of mean platelet volume (MPV) levels in brucellosis patients. Cumhuriyet Med J. 2013;35(4):488-494. http://dx.doi.org/10.7197/1305-0028.2295
  • Togan T, Narci H, Turan H, Ciftci O, Kursun E, Arslan H. The impact of acute brucellosis on mean platelet volume and red blood cell distribution. Jundishapur J Microbiol. 2015;8(2):e20039. https://doi.org/10.5812/jjm.20039