Early Outcomes of Aortic Valve Bicuspidization Using Autologous Pericardium in Pediatric Aortic Stenosis: a Preliminary Case Series

Bakhytzhan Nurkeyev 1, Amangeldy Kerimkulov 1, Assiya Akhmoldayeva 1, Elmira Kuandykova 1, Bagzhan Omiraliev 1, Arailym Kenzhebayeva 1, Akkerbez Adilbekova 1 *
More Detail
1 Pediatric Cardiac Surgery Department, National Scientific Medical Center, Astana, Kazakhstan
* Corresponding Author
J CLIN MED KAZ, Volume 22, Issue 4, pp. 81-83. https://doi.org/10.23950/jcmk/16610
OPEN ACCESS 528 Views 39 Downloads
Download Full Text (PDF)
Author Contributions: Conceptualization, A. A.; methodology, A. A., B. N.; validation, A. A., B. N., A. K.; writing – A. A., A. A., E. K.; original draft preparation, A. A., O. B., E. K., A. K.; writing – A. A., A. K., B. N., A. K., review and editing, A. A., A.A., O. B.; supervision, A. A., B. N., A. K.; All authors have read and agreed to the published version of the manuscript.

Consent statement: Written informed consent was obtained from the legal guardians of all patients for publication of this case series.

Data availability statement: The corresponding author can provide the data supporting the study's conclusions upon request. Due to ethical and privacy constraints, the data are not publicly accessible.

ABSTRACT

     Aortic valve bicuspidization using autologous pericardium is a promising valve-sparing technique for treating aortic stenosis in pediatric patients. However, literature describing this procedure in children remains limited. 
     To present early clinical outcomes of aortic valve bicuspidization with autologous pericardium in a small case series of pediatric patients with aortic stenosis.
     We conducted a retrospective analysis of five pediatric patients who underwent aortic valve bicuspidization using autologous pericardial patches in January 2025. Data were collected on surgical technique, echocardiographic findings, and postoperative complications.
     All five patients had successful surgical outcomes, with significant reductions in transvalvular gradients and no intraoperative or early postoperative complications. Valve function remained stable during follow-up (up to three months), and no reintervention was required.   
    This preliminary case series demonstrates the technical feasibility and short-term safety of aortic valve bicuspidization using autologous pericardium in children. Larger, longer-term studies are needed to validate these findings.
Keywords: Aortic stenosis, pediatric cardiac surgery, aortic valve repair, valve-sparing techniques.

CITATION

Nurkeyev B, Kerimkulov A, Akhmoldayeva A, Kuandykova E, Omiraliev B, Kenzhebayeva A, et al. Early Outcomes of Aortic Valve Bicuspidization Using Autologous Pericardium in Pediatric Aortic Stenosis: a Preliminary Case Series. J CLIN MED KAZ. 2025;22(4):81-3. https://doi.org/10.23950/jcmk/16610

REFERENCES

  • Singh GK. Congenital aortic valve stenosis. Children. 2019; 6(5): 69. https://doi.org/10.3390/children6050069
  • Seidalin A, Tuganbekov T, Dikolayev V, Aitaliyev S. Aortopathy pathophysiology features in patients with bicuspid aortic valve.. Journal of Clinical Medicine of Kazakhstan. 2016; 3(41): 14–20. https://doi.org/10.23950/1812-2892-2016-3-14-20
  • Yasuhara J, Schultz K, Bigelow AM, Garg V. Congenital aortic valve stenosis: from pathophysiology to molecular genetics and the need for novel therapeutics. Front Cardiovasc Med. 2023; 10: 1142707. https://doi.org/10.3389/fcvm.2023.1142707
  • Dikolayev V, Albazarov A, Tuganbekov T, et al. Comparative aspects of surgical treatment of the patients with thoracic aorta diseases. Journal of Clinical Medicine of Kazakhstan. 2019; 2(52): 42–49. https://doi.org/10.23950/1812-2892-JCMK-00686
  • Konstantinov IE, Bacha E, Barron D, David T, Dearani J, d’Udekem Y, El-Hamamsy I, Najm HK, del Nido PJ, Pizarro C, Skillington P, Starnes VA, Winlaw D. Optimal timing of Ross operation in children: A moving target? J Thorac Cardiovasc Surg. 2024; 168(5): 1310–1320.e1. https://doi.org/10.1016/j.jtcvs.2024.02.012
  • Marathe SP, Baird CW. Surgical management of congenital aortic and truncal valve disease: A comprehensive review. Semin Thorac Cardiovasc Surg Pediatr Card Surg Annu. 2025; 28: 29–37. https://doi.org/10.1053/j.pcsu.2025.03.001
  • Konstantinov IE, Zubritskiy A. Do we all need to learn aortic valve repair the HAART way? J Thorac Cardiovasc Surg. 2024; 167(3): e74–e75. https://doi.org/10.1016/j.jtcvs.2023.08.034
  • Schäfers HJ, Konstantinov IE. Surgical anatomy of aortic root: Toward precise and durable aortic, neo-aortic, and truncal valve repairs. J Thorac Cardiovasc Surg. 2024; 169(5): 1287–1295. https://doi.org/10.1016/j.jtcvs.2024.10.010
  • Ozaki S, Kawase I, Yamashita H, Uchida S, Takatoh M, Hagiwara S, Kiyohara N. Aortic valve reconstruction using autologous pericardium for aortic stenosis. Circ J. 2015; 79(7): 1504–1510. https://doi.org/10.1253/circj.CJ-14-1092
  • Ozaki S, Kawase I, Yamashita H, Uchida S, Nozawa Y, Takatoh M, Hagiwara S. A total of 404 cases of aortic valve reconstruction with glutaraldehyde-treated autologous pericardium. J Thorac Cardiovasc Surg. 2014; 147(1): 301–306. https://doi.org/10.1016/j.jtcvs.2012.11.012
  • Schäfers HJ. Standardized aortic valve repair in pediatric patients. J Thorac Cardiovasc Surg. 2023; 166(2): 292–293. https://doi.org/10.1016/j.jtcvs.2022.10.019
  • d'Udekem Y, Kisamori E, Ishigami S, Konstantinov IE. Aortic valve-sparing procedure in the pediatric population. Ann Cardiothorac Surg. 2023; 12(3): 253–258. https://doi.org/10.21037/acs-2023-avs1-0029