Effect of infusion solutions on the dynamics of neuronspecific enolase activity in patients with acute cerebral ischemia

Влияние инфузионных растворов на уровень нейрон-специфической энолазы у пациентов с острой церебральной ишемией
Andrey Semenenko 1
More Detail
1 National Pirogov Memorial Medical University of Vinnytsia, Department of Surgery №1, Vinnytsia Ukraine
J CLIN MED KAZ, Volume 4, Issue 38, pp. 42-45.
OPEN ACCESS 2913 Views 1946 Downloads
Download Full Text (PDF)

ABSTRACT

Objective: To investigate the dynamics of NSE during treatment of isoosmolar 0.9% NaCl solution and the hyperosmolar mannitol solution in acute ischemic stroke.
Methods: It was studied 15 patients with acute ischemic stroke. The investigated isoosmolar 0.9% Nacl solution and the solution hyperosmolar mannitol administered intravenously in a conventionally effective dose (defined in the experiment) directly upon confirmation of the diagnosis of acute ischemic stroke and further every day, every 12 hours for 7 days. A control group were patients treated with infusion therapy only 0.9% NaCl solution, the comparison group were patients treated with 0.9% NaCl solution + mannitol. Blood sampling was conducted for determination of specific marker of cerebral ischemia the neuron-specific enolase (1st, 4th and 7th day of stroke).
Results: Treatment of patients with acute ischemic stroke with mannitol was accompanied by the dynamic growth of the test marker of neurodestruction from 17 to 23 nm / ml in all periods of observation with a statistically significant increase in the activity of NSE on the seventh day of stroke. A similar picture is viewed in the group with 0.9% NaCl solution.
Conclusion: infusion therapy with isoosmolar 0.9% NaCl solution + hyperosmolar mannitol with standard therapy was accompanied by a dynamic growth of NSE in patients with acute cerebrovascular accident on ischemic type as in the control group.
Keywords: acute disorder of cerebral circulation, 0.9% NaCl solution, mannitol

CITATION

Semenenko A. Effect of infusion solutions on the dynamics of neuronspecific enolase activity in patients with acute cerebral ischemia. Journal of Clinical Medicine of Kazakhstan. 2015;4(38):42-5.

REFERENCES

  • Anisimova A.V., Krupatkin A.I., Sidorov V.V. et al. Osobennosti sostojanija mikrocirkuljacii v pacientov s ostrym ishemicheskogo insul’tom i hronicheskoj ishemiej golovnogo mozga (Features of microcirculation in patients with acute ischemic stroke and chronic cerebral ischemia), Zhurnal nevrologii i psihiatrii im. C.C. Korsakova, 2015, No.3, рр.27-32. (in Russian)
  • Grigorev E. V., Vavin G. V., Grishanova T. G. et al. Neyronspetsificheskie belki - markeryi entsefalopatii pri tyazheloy sochetannoy travme (Neurospecific proteins are markers encephalopathy with severe concomitant injury), Meditsina neotlozhnyih sostoyaniy, 2010, No.2 (27), рр.72-76. (in Ukraine)
  • Zozulja I. S., Zozulja A. I. Mozgovoj insul’t: nastojashhee i perspektivy (Stroke: present and prospects) Jekstrennaja medicina, 2014, No.4 (12), рр.8-14.
  • Linskaja G. V. Kliniko-gemodinamicheskie osobennosti raznyh podtipov ishemicheskogo insul’ta v ostrom periode (Clinical and hemodynamic characteristics of different subtypes of ischemic stroke in the acute period), Ukrainskij vestnik psihonevrologii, 2015, Vol.23, No.2 (83), рр.6-12. (in Ukraine)
  • Maksimova M. Ju., Suslina Z. A., Ionova V. G. Gemoreologija i gemostaz v ostrejshem periode lakunarnogo insul’ta (Hemorheology and hemostasis in acute period lacunar stroke), Zhurnal nevrologii i psihiatrii im. S. S. Korsakova, 2007, Vol.107, No.12, pp.4-7. (in Russian)
  • Petrik I. A., Hodakovskaja A. V., Shtrygol’ S. Ju. et al. Modulirujushhee dejstvie proizvodnogo 3,2’-Spiro-pirrola-2- oksindola na formirovanie steroidnoj nejrotoksichnosti, kardiocerebral’noj disfunkcii i techenie nejroapoptoza v uslovijah jeksperimental’nogo ishemicheskogo insul’ta (Modulating effect derivative 3,2’-Spiro-pyrrole-2-oxindole formation steroid neurotoxicity cardiocerebral dysfunction and for neyroapoptoza in experimental ischemic stroke), Vrach-aspirant, 2014, No.6 (67), pp.44-53. (in Russian)
  • Piskunov A. K. Biomarkery nejrovospalenija (Biomarkers neuroinflammation), Nejrohimija. 2010, Vol.27, No.1, pp.63-73. (in Russian)
  • Reven’ko I. L. Jepidemiologija insul’ta v Ukraine (Epidemiology of stroke in the Ukraine), Zaporozhskij medicinskij zhurnal, 2010, No.3 (12), pp.42-47. (in Ukraine)
  • Hodakovskij A. A. Nejromorfologicheskaja ocenka jeffektivnosti Ademola v ostrom periode model’nogo narushenija mozgovogo krovoobrashhenija (Neuromorphological evaluation Ademola of the effectiveness of the model in acute cerebrovascular accident), Chelovek i ego zdorov’e, 2013, No.1, pp.32-37. (in Russian)
  • Хodakovskij A.A. Ocenka vlijanija jeksperimental’noj terapii Ademola na intensivnost’ protekanija destruktivnyh izmenenij v membranah nejronov v mongol’skih peschanok v uslovijah ostroj cerebral’noj ishemii (Assessing the impact of the experimental therapy Ademola on the intensity of the flow of destructive changes in the membranes of neurons in Mongolian gerbils in acute cerebral ischemia), Vestnik morfologii, 2011, Vol.17, No.1, pp. 62-65. (in Ukraine)
  • Nagaraja T. N., Keenan K. A., Aryal M. P. et al. Extravasation into brain and subsequent spread beyond the ischemic core of a magnetic resonance contrast agent following a step-down infusion protocol in acute cerebral ischemia, Fluids Barriers CNS, 2014, No.23, pp.11-21.
  • James D. Geyer, Camilo R. Gomez. Stroke. A practical approach, Lippincott Williams & Wilkins, 2009, 361 p.