Evaluation of the ability of the C-reactive protein-to-albumin ratio to predict short-term mortality in patients with COVID-19

Serdar Özdemir 1 * , Abdullah Algin 1 2
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1 University of Health Sciences Turkey, Ümraniye Training and Research Hospital, Clinic of Emergency Medicine, İstanbul, Turkey
2 University of Health Sciences Turkey, Somalia Mogadishu Recep Tayyip Erdogan Faculty of Health Sciences, Mogadishu, Somalia
* Corresponding Author
J CLIN MED KAZ, Volume 18, Issue 6, pp. 35-39. https://doi.org/10.23950/jcmk/11324
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This study aimed to determine the ability of the C-reactive protein (CRP)-to-albumin ratio (CAR) to predict short-term mortality in patients with COVID-19.
Material and methods
This retrospective, observational, cohort study included patients with COVID-19. The patients’ demographics, clinical characteristics, CRP, albumin, CAR, blood urea nitrogen, creatinine, Troponin I and all-cause mortality within 30 days after admission were noted. The receiver operating characteristic curve analysis was performed, and odds ratios were calculated to determine the discriminative ability of the parameters.
A total of 103 patients with a median of age of 57 (20-92) years were included in the study. The rate of 30-day mortality was 4.8% for the study cohort. According to the best Youden’s index, the cut-off value for CRP was determined as 7 (sensitivity: 80%, specificity: 78.6%), and the area under curve (AUC) value was 0.801 (95% confidence interval: 71.1-87.3). According to the best Youden’s index, the cut-off value for CAR was 0.18 (sensitivity: 80%, specificity: 78.6%), and the area under curve (AUC) value was 0.806 (95% confidence interval: 71.6-87.7). There was no statistically significant difference between the AUC values of CRP and CAR (DeLong equality test, p = 0.938). The odds ratios of CRP (>7 mg/L) and CAR (>0.18) for 30-day mortality were 14.667 (95% confidence interval: 1.555-138.299) and 13.818 (95% confidence interval: 1.468-130.076), respectively.
CAR was not useful in predicting 30-day mortality in patients with COVID-19. The calculation of CAR rather than CRP had no clinically significant contribution to the prediction of 30-day mortality in this patient group.


Özdemir S, Algin A. Evaluation of the ability of the C-reactive protein-to-albumin ratio to predict short-term mortality in patients with COVID-19. J CLIN MED KAZ. 2021;18(6):35-9. https://doi.org/10.23950/jcmk/11324


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