FEATURES OF THE COURSE OF MYOCARDIAL INFARCTION IN THE ELDERLY

Kamilya Kedelbaeva 1 * , Salim Berkinbaev 1, Gulnar Dzhunusbekova 1, Meyramgul Tundybaeva 1, Aizhan Kubeyeva 1, Darya Utebaliyeva 1
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1 Department of Cardiology, S.D. Asfendiyarov Kazakh National Medical University, Almaty, Kazakhstan
* Corresponding Author
J CLIN MED KAZ, In press.
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ABSTRACT

Cardiovascular disease is a major contributor to morbidity, mortality and quality of life in people aged 60 and over. However, this age group of patients was not sufficiently included in large studies, in this regard, the management of elderly patients is an urgent problem in modern medicine.
The purpose of this review is to analyze of literature data on the characteristics comorbid pathology and senile asthenia as a predictor of unfavorable course and outcomes of acute myocardial infarction in patients 60 years of age and older. 
To analyze the literature, we searched for information on this issue in PubMed / MEDLINE, PMC, Web of Science, Scopus, The Сocrane Library.
Recent research data show that there are plenty of risk factors for worsening the course of AMI in patients aged 60 and over. The most important of them are considered to be high comorbidity, multivessel lesion of several pools, the presence of senile asthenia. All together lead to difficulties in diagnosing myocardial infarction, to forced polypharmacy and in some cases refraining from early invasive strategy, which worsens the course of the disease, increases the duration of hospital treatment, leads to frequent complications, thereby affects the prognosis of the disease and leads to the development of early disability in patients 60 years of age and older
In the vast majority of elderly patients, the development of acute myocardial infarction occurs against the background of a high prevalence of comorbid pathology, which in turn accelerates the development of senile asthenia and its progression.

CITATION

Kedelbaeva K, Berkinbaev S, Dzhunusbekova G, Tundybaeva M, Kubeyeva A, Utebaliyeva D. FEATURES OF THE COURSE OF MYOCARDIAL INFARCTION IN THE ELDERLY. J Clin Med Kaz. 2021.

REFERENCES

  • Shabunova A. A. et al. Mortality of the able-bodied population of Russia and Belarus as a threat to the demographic development of territories. Ekonomicheskiye i sotsial'nyye peremeny: fakty, tendentsii, prognoz (Economic and social changes: facts, trends, forecast). 2012; 2(20);83-97. (In Russian).
  • "Health of the population of the Republic of Kazakhstan and the activities of the healthcare organization in 2019". Statistical collection of the Ministry of Health of the Republic of Kazakhstan, Nur-Sultan 2020; p 16,196.
  • Chen HY, Gore JM, Lapane KL, et al. A 35-year Perspective (1975-2009) into the Longterm Prognosis and Hospital Management of Patients Discharged from the Hospital after a First Acute Myocardial Infarction. American Journal of Cardiology. 2015;116(1):24-29. DOI:http://dx.doi.org/10.1016/j.amjcard.2015.03.035
  • Wan He, Daniel Goodkind, and Paul Kowal, U.S. Census Bureau. International Population Reports, P95/16-1, An Aging World: 2015. U.S. Government Publishing Office, Washington, DC. 2016; 165. DOI:10.13140/RG.2.1.1088.9362
  • Nikolich-Žugich J, Goldman DP, Cohen PR, et al. Preparing for an Aging World: Engaging Biogerontologists, Geriatricians and the Society. J Gerontol A Biol Sci Med Sci 2016; 71(4): 435-44, doi: 10.1093/gerona/glv164.
  • Vladimir Arkhangelsky, Mikhail Denisenko, Valery Elizarov, Baurzhan Zhusupov, Gaziza Moldakulov. Report “Population Situation Analysis of the Republic of Kazakhstan”. UNFPA Kazakhstan 2019; 68-72. https://kazakhstan.unfpa.org.
  • Bubnova M.G., Barbarash O.L., Doletsky A.A., Krasnitsky V.B., Lebedev E.V.,et al. Acute ST elevation myocardial infarction: After care and secondary prevention. National Russian guidelines. Russian Journal of Cardiology. 2015;(1):6-52. (InRuss.) https://doi.org/10.15829/1560-4071-2015-1-6-52
  • McManus DD, Nguyen HL, Saczynski JS, et al. Multiple cardiovascular comorbidities and acute myocardial infarction: temporal trends (1990-2007) and impact on death rates at 30 days and 1 year. Clin Epidemiol 2012; 4: 115–23. DOI: 10.2147 / CLEP. S30883.
  • Lopes R.D., Gharacholou S.M., Holmes D.N. et al. Cumulative incidence of death and rehospitalization among the elderly in the first year after NSTEMI. Am J Med 2015;128(6):582–90. DOI: 10.1016/j.amjmed.2014.12.03.
  • Barnett K, Mercer SW, Norbury M, et al. Epidemiology of multimorbidity and implications for health care, research, and medical education: a cross-sectional study. Lancet. 2012;380(9836):37-43. doi:10.1016/S0140-6736(12)60240-2.
  • Guiding principles for the care of older adults with multimorbidity: an approach for clinicians: American geriatrics society expert panel on the care of older adults with multimorbidity. J Am Geriatr Soc. 2012;60(10):E1-E25. doi:10.1111/j.1532- 5415.2012.04188.x.
  • Fortin, M., Hudon, C., Haggerty, J. et al. Prevalence estimates of multimorbidity: a comparative study of two sources. BMC Health Serv Res 2010;10, 111. https://doi.org/10.1186/1472-6963-10-111.
  • Rocca W.A., Boyd C.M., Grossardt B.R., et al. Prevalence of multimorbidity in a geographically defined American population: patterns by age, sex, and race/ethnicity. Mayo Clin Proc. 2014;89(10):1336- 49. doi: 10.1016/j.mayocp.2014.07.010.
  • Oganov R.G., Simanenkov V.I., Bakulin I.G., Bakulina N.V., Barbarash O.L., Boytsov S.A., Boldueva S.A., Garganeeva N.P., Doshchitsin V L., Karateev A.E., Kotovskaya Yu.V., Lila A.M., Lukyanov M.M., Morozova T.E., Pereverzev A.P., Petrova M.M., Pozdnyakov Yu.M. ., Syrov A.V., Tarasov A.V., Tkacheva O.N., Shalnova S.A. Comorbid pathology in clinical practice. Diagnostic and treatment algorithms. Cardiovascular therapy and prevention. 2019; 18 (1): 5-66. (InRuss.) https://doi.org/10.15829/1728-8800-2019-1-5-66
  • Boytsov S., Yakushin S., Martsevich S., Lukyanov M., Nikulina N., Zagrebelny A., Vorobiev A., Pereverzeva K., Pravkina E., Deev A., Andrenko E., Ershova A., Meshkov A ., Myasnikov R., Serdyuk S., Kharlap M. Outpatient-polyclinic register of cardiovascular diseases in the Ryazan region (REKVAZA): main tasks, experience of creation and first results // RFK. 2013. No. 1. (InRuss.) URL: https://cyberleninka.ru/article/n/ambulatorno-poliklinicheskiy-registrkardiovaskulyarnyh-zabolevaniy-v-ryazanskoy-oblasti-rekvaza-osnovnyezadachi-opyt-sozdaniya-i (date of access: 28.10.2019).
  • V.T. Ivashkin, A.A. Sheptulin, I. V. Mayev et al. Clinical guidelines of the Russian Gastroenterological Association for the diagnosis and treatment of peptic ulcer // Ros journal of gastroenterology, hepatology, coloproctology 2016; 26 (6). (InRuss.)
  • Volevach L.V., Nafikova A.Sh., Khismatullina G.Ya. and other Indicators of the quality of life in persons with gastric ulcer of the duodenum // Medical Bulletin of Bashkortostan. 2016.t No. 6. S.11-15. (InRuss.)
  • Dodel R. Multimorbidity: concept, epidemiology and treatment. Nervenarzt. 2014;85(4):401-08. doi:10.1007/s00115-013-3937-y
  • Hall M, Dondo TB, Yan AT, et al. Multimorbidity and survival for patients with acute myocardial infarction in England and Wales: Latent class analysis of a nationwide population-based cohort. PLOS Medicine. 2018;15(3):e1002501. doi:10.1371/journal. pmed.1002501
  • Suaya J.A., Stason W.B., Ades P.A. et al. Cardiac rehabilitation and survival in older coronary patients. J Am Coll Cardiol 2009;54(1):25–33. DOI: 10.1016/j.jacc.2009.01.078
  • Ar’yev A. L., Ovsyannikova N. A., Ar’yeva G. T., Dzakhova S. D., Havinson V. Kh. Polimorbidnost' v geriatrii [Geriatric polymorbidity]. Prakticheskaya onkologiya [Practical Oncology], 2015; vol. 16, no. 3, pp. 83–90.
  • Fassa A-A, Urban P, Radovanovic D, et al. Impact of comorbidities on clinical presentation, management and outcome of patients with acute coronary syndrome. Cardiovascular Medicine 2010; 13: 155–61. DOI: 10.5167 / uzh-36335
  • Hall M, Dondo TB, Yan AT, et al. Multimorbidity and survival for patients with acute myocardial infarction in England and Wales: Latent class analysis of a nationwide population-based cohort. PLOS Medicine. 2018;15(3):e1002501. doi:10.1371/journal. pmed.1002501
  • Osipova OA, Bukatov VV. Features of myocardial infarction with ST segment elevation in patients of the older age group. Research Results in Biomedicine. 2020;6(3):402-416. Russian. DOI: 10.18413/2658-6533-2020-6-3-0-10.
  • Ginzburg ML, Kutishenko NP, Martsevich SYu, et al. The analysis of factors influencing the terms of hospital admission in patients with acute coronary syndrom (according to the LIS study data — Lyubertsy study on mortality rate in patients after acute myocardial infarction). Ratsional'naya farmakoterapiya v kardiologii (Rational Pharmacotherapy in Cardiology). 2012;8(5):738-745, doi.org/10.20996/1819-6446-2012-8-6-738-745 (In Russian)
  • Malay LN, Solokhina LV, Bukhonkina Yu.M., et al. Patient characteristics and hospital outcomes in patients with acute myocardial infarction: registrar data (Khabarovsk). Part 1. Ratsional'naya farmakoterapiya v kardiologii (Rational pharmacotherapy in cardiology). 2016; 12 (1): 56-62. doi.org/10.20996/1819-6446-2016-12-1-56-62 (In Russ.)
  • Tukish OV, Okrugin SA, Yunusova E.Yu., et al. Acute myocardial infarction in elderly and senile people: an epidemiological study under the WHO program “Register of acute myocardial infarction”. Uspekhi gerontologii=Advances in gerontology. 2016; 29 (1): 123-127. (In Russian)
  • Abbasi S. H., Boroumand M. A. Expanded network of inflammatory markers of atherogenesis: where are we now? Open Cardiovasc. Med. J., 2010; no. 4, pp. 38–44. doi: 10.2174/1874192401004020038
  • Nishida H., Horio T., Suzuki Y., Iwashima Y., Tokudome T., Yoshihara F., Nakamura S., Kawano Y. Interleukin-6 as an independent predictor of future cardiovascular events in high-risk Japanese patients: comparison with C-reactive protein. Cytokine, 2010, vol. 53, no. 3, pp. 342–346. doi: 10.1016/j.cyto.2010.12.005
  • Avilova, M. V. Multifocal atherosclerosis: the problem of combined atherosclerotic lesions of the coronary and brachiocephalic basins // Kreativnaya kardiologiya =Creative Cardiology. 2013; No. 1. - P. 5-13. (In Russian)
  • NICE. Multimorbidity: Clinical Assessment and Management. CG56, 2016. https://wwwniceorguk/guidance/ng56.
  • Alison J Yarnall, Avan A Sayer, Andrew Clegg, Kenneth Rockwood, Stuart Parker, John V Hindle New horizons in multimorbidity in older adults Age and Ageing, Volume 46, Issue 6, November 2017, Pages 882–888, https://doi.org/10.1093/ageing/afx150
  • Oganov R.G, Simanenkov V.I, Bakulin I.G, Bakulina N.V, Barbarash O.L, et al. Comorbidities in clinical practice. Algorithms for diagnostics and treatment All-Russian fund “Association of general practitioners (family doctors) of Russian Federation”, National medical Association for the Study of the Multimorbidity, Fund “PROFMEDFORUM” Kardiovaskulyarnaya terapiya i profilaktika = Cardiovascular Therapy and Prevention. 2019;18(1):5–66 http://dx.doi.org/10.15829/1728-8800-2019-1-5-66 (In Russian)
  • Ng T.P. Frailty in Older Persons: Multisystem Risk Factors and the Frailty Risk Index (FRI) / T.P. Ng, L. Feng, M.S. Nyunt, A. Larbi, K.B. Yap // J Am Med Dir Assoc. – 2014. – Vol. 15(9) – P. 635-642. doi: 10.1016/j.jamda.2014.03.008.
  • Pegorari M.S. Factors associated with the frailty syndrome in elderly individuals living in the urban area / M.S. Pegorari, D.M.d.S. Tavares Revista // Latino-Americana de Enfermagem. – 2014. – Vol. 22(5) – P. 874-882. doi: 10.1590/0104-1169.0213.2493.
  • Weiss, O. C. Frailty and Chronic Diseases in Older Adults / O.C. Weiss // Clin. Geriatr. Med. – 2011. - Vol.27. - P. 39–52. doi: 10.1016/j.cger.2010.08.003
  • Bandeen-Roche K., Varadhan R., Zhou J., Fried L.P. Initial Mani-festations of Frailty Criteria and the Development of Frailty Phe-notype in the Women's Health and Aging Study II. The Journals of Gerontology: Series A. 2008; 63: 9: 984–990. doi: 10.1093/gerona/63.9.984.
  • Díez-Villanueva P, Arizá-Solé A, Vidán MT, et al. Recommendations of the Geriatric Cardiology Section of the Spanish Society of Cardiology for the assessment of frailty in elderly patients with heart disease. Rev Esp Cardiol (Engl Ed) 2019; 72: 63–71, doi: 10.1016/j.rec.2018.06.035.
  • Bebb O, Smith FG, Clegg A, et al. Frailty and acute coronary syndrome: a structured literature review. Eur Heart J Acute Cardiovasc Care 2018; 7: 166–175, doi: 10.1177/2048872617700873
  • Sedova E.V., Paleev F.N., Prashchayeu K.I., Korshun E.I. Neuroimmune and endocrine mechanisms of unfavorable geriatric status in patients with acute coronary syndrome. Almanac of Clinical Medicine. 2017;45(3):225-233. (In Russ.) https://doi.org/10.18786/2072-0505-2017-45-3-225-233.
  • Paleev FN, Belokopytova IS, Minchenko BI, Moskalets OV. The role of cytokines in the pathophysiology of ischemic heart disease. Creative Cardiology. 2011;(1): 75–80. Russian
  • Halter JB, Hazzard WR. Hazzard's geriatric medicine and gerontology (6th ed.). Medical. 2009. 1634 p. ISBN 978-0-07-148872-3. MHID 0-07-148872-3
  • Elisabetta Tonet, Rita Pavasini, Simone Biscaglia, Gianluca Campo. Frailty in patients admitted to hospital for acute coronary syndrome: when, how and why? Journal of Geriatric Cardiology (2019) 16: 129-137; www.jgc301.com, doi: 10.11909/j.issn.1671-5411.2019.02.005
  • Sharabchiev Yu.T., Antipov V.V., Antipova S.I. Comorbidity is an urgent scientific and scientific-practical problem of medicine in the 21st century. Meditsinskiye novosti = Journal "Medical News". 2014.No. 8, P.6-11. (In Russ.)
  • Oganov R.G., Simanenkov V.I., Bakulin I.G., Bakulina N.V., Barbarash O.L., Boytsov S.A., et al. Comorbid pathology in clinical practice. Algorithms for diagnosis and treatment. Kardiovaskulyarnaya terapiya i profilaktika = Cardiovascular therapy and prevention. 2019; 18 (1): 5-66 http://dx.doi.org/10.15829/1728- 8800-2019-1-5-66 (In Russ.)
  • Ryzhkova Y.D., Kanareikina E.V., Atabegashvili M.R. et al. Acute coronary syndrome in the elderly: features of patient management. Klinicist= Clinician 2019; 13 (1-2): 19-26 DOI: 10.17650 / 1818-8338-2019-13-1-2-19-26 (In Russian)
  • Samorodskaya IV. Screening in Cardiology. Kompleksnyye problemy serdechno-sosudistykh zabolevaniy= Complex problems of cardiovascular diseases. 2018;7(4):92- 100, doi:10.17802/2306-1278-2018-7-4-92-100 (In Russ.)
  • Alonso-Morán E, Nuño-Solinis R, Onder G, Tonnara G. Multimorbidity in risk stratification tools to predict negative outcomes in adult population. Eur J Intern Med. 2015;26(3):182-9. doi:10.1016/j.ejim.2015.02.010.