Features of the endocrine system of female adolescents in cotton-growing regions

Особенности эндокринного статуса девочек-подростков, жительниц хлопкосеющих регионов
Gauri Bapayeva 1, Saltanat Kulbayeva 2, Akmaral Zhumadilova 3
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1 Department of obstetrics and gynecology, National research center for maternal and child health of the corporate fund «UMC», Astana, Kazakhstan
2 South Kazakhstan State Pharmaceutical Academy, Shymkent, Kazakhstan
3 Akhmet Yassawi International Kazakh-Turkish University
J CLIN MED KAZ, Volume 3, Issue 45 special issue, pp. 29-34. https://doi.org/10.23950/1812-2892-JCMK-00495
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ABSTRACT

Objective: to study the features of the endocrine system during the puberty in females living in regions, where organochlorine pesticides are widely used. Materials and Methods:172 females (adolescents aged 10-17) were examined. They were divided into 2 groups, depending on their place of residence. The frst (main) group included 89 females who from birth lived in a territory where organochlorine pesticides were widely used to grow cotton. The second (control) group included 83 females that did not live in such areas. Gonadotropic hormones – follicle stimulating (FSH), luteinizing (LH), prolactin (PL) – and steroid hormones – estradiol (E2), cortisol (K), dehydroepiandrosterone (DHEA) – were examined in all girls.
Results: It was found that the levels of FSH and LH in the females of the main group were signifcantly lower (p>0.02) during the whole period of puberty compared to their peers. Thus, the level of FSH at the age of 15-17 years was in the main group - 10.79 ± 0.98 mU / l compared to 16.26 ± 0.21 mU / l, and the level of LH - 10.95 ± 0.66 mU / L and 18.42 ± 1.28 mU / l, respectively. A similar pattern has been established with respect to prolactin at the age of 10-12 years and 13-14 years.
Conclusion: the females of the main group have a decreased production of gonadotropic and steroid hormones in the period of the formation of the reproductive system,.

CITATION

Bapayeva G, Kulbayeva S, Zhumadilova A. Features of the endocrine system of female adolescents in cotton-growing regions. Journal of Clinical Medicine of Kazakhstan. 2017;3(45 special issue):29-34. https://doi.org/10.23950/1812-2892-JCMK-00495

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