Health related quality of life in patients with primary biliary cholangitis

Fahad Abdallah Yassin 1 * , Azar Abiyev 2, Mustafa Ergin 2, Nergiz Ekmen 2, Mehmet İbiş 2
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1 Department of Internal Medicine, Medical Faculty, Gazi University, Ankara, Turkey
2 Department of Gastroenterology, Medical Faculty, Gazi University, Ankara, Turkey
* Corresponding Author
J CLIN MED KAZ, Volume 19, Issue 4, pp. 40-43. https://doi.org/10.23950/jcmk/12292
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ABSTRACT

Aim: To assess the health related quality of life (HRQOL) in patients diagnosed with primary biliary cholangitis (PBC).
Material and methods: A single-centered, prospective, cross-sectional study was conducted among patients diagnosed with primary biliary cholangitis in the Gastroenterology out-patient clinic at Gazi University Hospital, Ankara. Data was collected using a sociodemographic information form, hospital medical database and a PBC-40 questionnaire. Statistical comparison analysis was performed using Chi-square test for categorical variables and Mann-Whitney U test for continuous variables. P values less than 0.05 were considered significant.
Results: A total of 37 PBC patients were included in the study. The mean age of the participants was 54.2±8.6. When evaluating the PBC-40 questionnaire scores from each domain in terms of severity, we found that majority of patients in itch %40.4 (n=19) and social %42,6 (n=20) domains had mild severity, as for fatigue %42.6 (n=20), cognitive %36 (n=17), emotional %40.4 (n=19) and other symptoms %44.7 ((n=21) domains had moderate severity. A statistically significant difference was found between AMA positive and AMA negative patient groups in the itch domain (p=0.007).
Discussion: With this study on a Turkish based population using the PBK-40 questionnaire we were able to demonstrate that patients with PBC had a significantly impaired HRQOL and fatigue was the most seen symptom.
Keywords: primary biliary cholangitis, health related quality of life, PBC-40

CITATION

Yassin FA, Abiyev A, Ergin M, Ekmen N, İbiş M. Health related quality of life in patients with primary biliary cholangitis. J CLIN MED KAZ. 2022;19(4):40-3. https://doi.org/10.23950/jcmk/12292

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