Health related quality of life in patients with primary biliary cholangitis

Fahad Abdallah Yassin 1 * , Azar Abiyev 2, Mustafa Ergin 2, Nergiz Ekmen 2, Mehmet İbiş 2
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1 Department of Internal Medicine, Medical Faculty, Gazi University, Ankara, Turkey
2 Department of Gastroenterology, Medical Faculty, Gazi University, Ankara, Turkey
* Corresponding Author
J CLIN MED KAZ, In press.
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ABSTRACT

Aim: To assess the health related quality of life (HRQOL) in patients diagnosed with primary biliary cholangitis (PBC).
Material and methods: A single-centered, prospective, cross-sectional study was conducted among patients diagnosed with primary biliary cholangitis in the Gastroenterology out-patient clinic at Gazi University Hospital, Ankara. Data was collected using a sociodemographic information form, hospital medical database and a PBC-40 questionnaire. Statistical comparison analysis was performed using Chi-square test for categorical variables and Mann-Whitney U test for continuous variables. P values less than 0.05 were considered significant.
Results: A total of 37 PBC patients were included in the study. The mean age of the participants was 54.2±8.6. When evaluating the PBC-40 questionnaire scores from each domain in terms of severity, we found that majority of patients in itch %40.4 (n=19) and social %42,6 (n=20) domains had mild severity, as for fatigue %42.6 (n=20), cognitive %36 (n=17), emotional %40.4 (n=19) and other symptoms %44.7 ((n=21) domains had moderate severity. A statistically significant difference was found between AMA positive and AMA negative patient groups in the itch domain (p=0.007).
Discussion: With this study on a Turkish based population using the PBK-40 questionnaire we were able to demonstrate that patients with PBC had a significantly impaired HRQOL and fatigue was the most seen symptom.

CITATION

Yassin FA, Abiyev A, Ergin M, Ekmen N, İbiş M. Health related quality of life in patients with primary biliary cholangitis. J Clin Med Kaz. 2022.

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