Peripheral blood lymphocytes apoptosis role in rheumatoid arthritis progressing

Raisa Aringazina 1 * , Nazgul Seitmaganbetova 2, Aigul Mussina 3, Yuliya Zame 4, Samat Saparbayev 5, Nurgul Zholdassova 6, Indira Kaibagarova 3
More Detail
1 Department of Internal Diseases No 1, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan
2 Department of Propedeutics of Internal Diseases, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan
3 Department of Clinical Pharmacology, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan
4 Department of Children's Diseases No 1 with Neonatology, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan
5 Department for Scientific Work, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan
6 Department of Therapeutic and Orthopaedic Dentistry, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan
* Corresponding Author
J CLIN MED KAZ, Volume 20, Issue 4, pp. 4-9. https://doi.org/10.23950/jcmk/13527
OPEN ACCESS 643 Views 434 Downloads
Download Full Text (PDF)

ABSTRACT

Rheumatoid arthritis (RA) is an autoimmune, chronic, and genetically linked inflammatory lesion of joint tissues that is accompanied by extra-articular systemic pathologies. The disease progression leads to joints immobilization, and eventually, the patient's disability occurs approximately ten years from the first clinical manifestation. RA pathogenesis involves various mechanisms: specific joint-related damage, nonspecific adaptive, and vessel-related pathological changes. Our research aimed to study the role of peripheral blood lymphocyte apoptosis in RA pathogenesis. We have analyzed research data from Google Scholar, PubMed, Web of Science, and Scopus databases to investigate the role of lymphocyte apoptosis in RA progression. Clinical manifestations in RA are caused by autoreactive T- and B-lymphocyte activity supported by humoral and cellular immune factors activity. Disease pathogenesis is caused by an imbalance in the process of programmed cell death (apoptosis): a proportion of immune cells are rapidly destroyed. In contrast, apoptosis is inhibited in the other classes of immune cells. High infiltration of the joint by autoreactive sensitized lymphocytes worsens the patient's condition. Apoptosis inhibition is especially noticeable in the early stages of RA and correlates with the concentration of the anti-apoptotic molecule Bcl-2 in the synovia. Activating the apoptotic destruction of lymphocytes (by drug action) allows a positive therapeutic effect and sustained remission. However, it should be noted that genetic factors play a significant role in the onset, progression and drug response of RA. In addition, environmental and behavioral factors can activate RA progression and influence treatment efficacy.
Keywords: apoptosis, rheumatoid arthritis, lymphocytes, joint, blood serum, genetic factors, pathogenesis, treatment.

CITATION

Aringazina R, Seitmaganbetova N, Mussina A, Zame Y, Saparbayev S, Zholdassova N, et al. Peripheral blood lymphocytes apoptosis role in rheumatoid arthritis progressing. J CLIN MED KAZ. 2023;20(4):4-9. https://doi.org/10.23950/jcmk/13527

REFERENCES

  • Liu L, Zuo Y, Xu Y, Zhang Z, Li Y, Pang J. MiR-613 inhibits proliferation and invasion and induces apoptosis of rheumatoid arthritis synovial fibroblasts by direct down-regulation of DKK1. Cell Mol Biol Lett. 2019;24:1-14. https://doi.org/10.1186/s11658-018-0130-0
  • Valieva МYu, Maksumova DК, Ganieva IU, Valieva ZS. Features of the spread of rheumatoid arthritis among the unorganised population of the Andijan region. [in Russian]. Vopr Nauki i Obrazov. 2020;(23 (107)):51-53.
  • Catrina AI, Svensson CI, Malmstrom V, Schett G, Klareskog L. Mechanisms leading from systemic autoimmunity to joint-specific disease in rheumatoid arthritis. Nat Rev Rheumatol. 2017;13:79-86. https://doi.org/10.1038/nrrheum.2016.200
  • Radner H, Lesperance T, Accortt NA, Solomon DH. Incidence and prevalence of cardiovascular risk factors among patients with rheumatoid arthritis, psoriasis, or psoriatic arthritis. Arthritis Care Res (Hoboken). 2017;69:1510-1518. https://doi.org/10.1002/acr.23171
  • Cojocaru M, Cojocaru IM, Silosi I, Vrabie CD, Tanasescu R. Extra-articular manifestations in rheumatoid arthritis. Maedica. 2010;5(4):286. PMID: 21977172
  • Truhan DI, Ivanova DS, Belus КD. Rheumatoid arthritis and traditional cardiovascular risk factors: current aspects of real clinical practice. [in Russian]. Consil Medicum. 2020;22(1):19-25. https://doi.org/10.26442/20751753.2020.1.200052
  • Tilloeva ShSh. Study of the rheumatoid arthritis spread in the Bukhara region. [in Russian]. Centr Asian J Med Natural Sci. 2021;428-431. https://doi.org/10.47494/cajmns.vi0.457
  • Giannini D, Antonucci M, Petrelli F, Bilia S, Alunno A, Puxeddu I. One year in review 2020: pathogenesis of rheumatoid arthritis. Clin Exp Rheumatol. 2020;38(3):387-97. https://doi.org/10.55563/clinexprheumatol/3uj1ng
  • Lopez-Pedrera C, Barbarroja N, Patiño-Trives AM, Luque-Tévar M, Collantes-Estevez E, Escudero-Contreras A, Pérez-Sánchez C. Effects of biological therapies on molecular features of rheumatoid arthritis. Intern J Mol Sci. 2020;21(23):9067. https://doi.org/10.3390/ijms21239067
  • Catrina AI, Joshua V, Klareskog L, Malmström V. Mechanisms involved in triggering rheumatoid arthritis. Immunol Rev. 2016;269(1):162-174. https://doi.org/10.1111/imr.12379
  • Almutairi K, Nossent J, Preen D, Keen H, Inderjeeth C, Almutairi K, et al. The global prevalence of rheumatoid arthritis: a meta-analysis based on a systematic review. Rheumatol Int. 2021;41:863-877. https://doi.org/10.1007/s00296-020-04731-0
  • Khir NAM, Noh ASM, Long I, Ismail NI, Siran R, Ismail CAN. Inflammatory-associated apoptotic markers: are they the culprit to rheumatoid arthritis pain? Mol. Biol. Rep. 2022;49(10):10077-10090. https://doi.org/10.1007/s11033-022-07591-y
  • Zhao J, Jiang P, Guo S, Schrodi SJ, He D. Apoptosis, autophagy, NETosis, necroptosis, and pyroptosis mediated programmed cell death as targets for innovative therapy in rheumatoid arthritis. Frontiers Immun. 2021;12:5652. https://doi.org/10.3389/fimmu.2021.809806
  • Grilo AL, Mantalaris A. Apoptosis: A mammalian cell bioprocessing perspective. Biotech Advanc. 2019;37(3):459-475. https://doi.org/10.1016/j.biotechadv.2019.02.012
  • Dubikov АI, Kalichenniko SG, Matveeva NYu. Apoptosis as a factor of autoimmune inflammation organization in rheumatoid arthritis. [in Russian]. Sovremen Revmatol. 2019;13(3):95-101. https://doi.org/10.14412/1996-7012-2019-3-95-101
  • McIlwain DR, Berger T, Mak TW. Caspase functions in cell death and disease. Cold Spring Harb Perspect Biol. 2015;7(4):a026716. https://doi.org/10.1101/cshperspect.a026716
  • Cha HS, Bae EK, Ahn JK, Lee J, Ahn KS, Koh EM. Slug suppression induces apoptosis via Puma transactivation in rheumatoid arthritis fibroblast-like synoviocytes treated with hydrogen peroxide. Exp Mol Med. 2010;42(6):428-436. https://doi.org/10.3858/emm.2010.42.6.044
  • Wang Y, Hou L, Yuan X, Xu N, Zhao S, Yang L, Zhang N. miR-483-3p promotes cell proliferation and suppresses apoptosis in rheumatoid arthritis fibroblast-like synoviocytes by targeting IGF-1. Biomed Pharmacot. 2020;130:110519. https://doi.org/10.1016/j.biopha.2020.110519
  • Pericolini E, Alunno A, Gabrielli E, Bartoloni E, Cenci E, Chow S, et al. The Microbial Capsular Polysaccharide Galactoxylomannan Inhibits IL-17A Production in Circulating T Cells From Rheumatoid Arthritis Patients. PloS One. 2013;8(1):e53336. https://doi.org/10.1371/journal.pone.0053336
  • Zhang X, Burch E, Cai L, So E, Hubbard F, Matteson E, et al. CD40 Mediates Downregulation of CD32B on Specific Memory B Cell Populations in Rheumatoid Arthritis. J Immunol. 2013;190(12):6015-6022. https://doi.org/10.4049/jimmunol.1203366
  • Goltsev AN, Ostankova LV, Rassokha IV. Contribution of Apoptosis to Rheumatosis Arthritis Pathogenesis. Probable Ways for the Process Control. Probl Cryobiol Cryomed. 2002;(3):52-58. http://journal.cryo.org.ua/index.php/probl-cryobiol-cryomed/article/view/960
  • Liu Н, Pope RM. The role of apoptosis in rheumatoid arthritis. Cur Opin Pharm. 2003;3(3):317-322. https://doi.org/10.1016/S1471-4892(03)00037-7
  • Zaichko K, Zaichko N, Maievskyi O, Korotkyi O, Falalyeyeva T, Fagoonee S, et al.. Circadian Rhythms of Endothelial Nitric Oxide Synthase and Toll-like Receptors 2 Production in Females with Rheumatoid Arthritis Depending on NOS3 Gene Polymorphism. Rev Recent Clinic Trials. 2020;15(2):145-151. https://doi.org/10.2174/1574887115666200416143512
  • Dong H, Strome S, Matteson E, Moder K, Flies D, Zhu G, et al. Costimulating aberrant T cell responses by B7-H1 autoantibodies in rheumatoid arthritis. J Clin Invest. 2003;111(3):363-370. https://doi.org/10.1172/jci16015
  • Liu H, Pope RM. Apoptosis in rheumatoid arthritis: friend or foe. Rheumatic Dis Clinics. 2004;30(3):603-625. https://doi.org/10.1016/j.rdc.2004.04.010
  • Greenblatt HK, Kim H-A, Bettner LF, Deane KD. Preclinical rheumatoid arthritis and rheumatoid arthritis prevention. Cur Opin Rheum. 2020;32(3):289-296. https://doi.org/10.1097/BOR.0000000000000708
  • Radu, A.F., & Bungau, S.G. Management of Rheumatoid Arthritis: An Overview. Cells. 2021;10(11):2857. https://doi.org/10.3390/cells10112857
  • McInnes IB, Schett G. Pathogenetic insights from the treatment of rheumatoid arthritis. Lancet. 2017;389(10086):2328-2337. https://doi.org/10.1016/S0140-6736(17)31472-1
  • Burmester GR, Pope JE. Novel treatment strategies in rheumatoid arthritis. Lancet. 2017;389(10086):2338-2348. https://doi.org/10.1016/S0140-6736(17)31491-5
  • Lin YJ, Anzaghe M, Schülke S. Update on the pathomechanism, diagnosis, and treatment options for rheumatoid arthritis. Cells. 2020;9(4):880. https://doi.org/10.3390/cells9040880
  • Aletaha D, Smolen JS. Achieving clinical remission for patients with rheumatoid arthritis. Jama. 2019;321(5):457-458. https://doi.org/10.1001/jama.2018.21249
  • Rapetti L, Chavele K, Evans C, Ehrenstein M. B Cell Resistance to Fas-Mediated Apoptosis Contributes to Their Ineffective Control by Regulatory T Cells in Rheumatoid Arthritis. Ann Rheum Dis. 2015;74(1):294-302. https://doi.org/10.1136/annrheumdis-2013-204049
  • Dudkov АV. Peptid regulation caspase-related apoptosis in cell senescence. регуляция каспаза-зависимого апоптоза при клеточном старении. [in Russian]. Vopr Nauki i Obrazov. 2019;(2):140-140. https://doi.org/10.17513/spno.28701
  • Smolen JS, Landewé RB, Bijlsma JW, Burmester GR, Dougados M, Kerschbaumer A, et al. EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2019 update. Annals Rheum Dis. 2020;79(6):685-699. http://dx.doi.org/10.1136/annrheumdis-2019-216655
  • Volkova МV. Predicting the efficacy of tocilizumab and rituximab in rheumatoid arthritis. Zhurnal Grodn Gos Med Univ. 2019;17(5):560-564. https://doi.org/10.25298/2221-8785-2019-17-5-560-564
  • Aringazina R, Myasoutova L, Babaskina L, Pashanova O. Correlation of pharmacokinetic disposition of methotrexate and serum cytokine levels in rheumatoid arthritis patients. Bangladesh J Med Sci. 2022;21(2):335-343. https://doi.org/10.3329/bjms.v21i2.58066
  • López-Rodríguez R, Ferreiro-Iglesias A, Lima A, Bernardes M, Pawlik A, Paradowska-Gorycka A, et al. Replication study of polymorphisms associated with response to methotrexate in patients with rheumatoid arthritis. Sci Rep. 2018;8:7342. https://doi.org/10.1038/s41598-018-25634-y
  • Madrid-Paredes A, Martín J, Márquez A. -Omic approaches and treatment response in rheumatoid arthritis. Pharmaceutics. 2022;14(8):1648. https://doi.org/10.3390/pharmaceutics14081648
  • Nasonov ЕL. Methotrexate in rheumatoid artritis-2015: new facts and ideas. [in Russian]. Nauch-Pract Revmatol. 2015;53(4):421-433. http://dx.doi.org/10.14412/1995-4484-2015-421-433