Prognostic Factors and Survival of Women with Breast Cancer Under 40 Years Old: A Single-Centre Experience

Berrin Inanc 1 * , Ozlem Mermut 1
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1 Department of Radiation Oncology, University of Health Sciences, Istanbul Education and Research Hospital, Istanbul, Turkey
* Corresponding Author
J CLIN MED KAZ, Volume 3, Issue 57, pp. 39-44.
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Objective: This retrospective research aimed to evaluate the results of treatment outcome and clinicopathological features of breast cancer patients under 40 years old.
Material and methods: A total of 80 patients who were receiving radiotherapy and/or chemotherapy treatment for breast cancer (<40 years old) were included in the study. 
Results: First-degree relatives with breast cancer history (p=0.028), oestrogen receptor positivity (p=0.012) and progesterone receptor positivity (p=0.017) were associated with overall survival. No prognostic factors were found in the multivariate Cox regression analysis for overall survival. In multivariate Cox regression analysis, we found breast-conserving surgery type (hazard ratio = 6.104. 95% confidence interval = 1.037–53.928, p=0.045), lymphovascular invasion presence (hazard ratio = 0.127, 95% confidence interval = 0.016–1.025, p=0.005) and curative radiotherapy doses (hazard ratio = 185.976, 95% confidence interval = 5.342–6474.1, p=0.004) as independent prognostic factors for disease-free survival. Overall, survival of 1, 3 and 5 years was 88%, 74% and 65%, respectively. Median was 48±2.6 (42.8–53.19) months. Also, 1-, 3- and 5-year disease-free survival was 85%, 67% and 27%, respectively. Median was 30±1.8 (27.4–32.5) months.
Conclusion: Breast cancer patients under the age of 40 years are highly heterogeneous and are a complex patient group. The prognosis is worse in these patients, and prognostic factors and pathological subtypes should be taken into consideration when making treatment decisions.


Inanc B, Mermut O. Prognostic Factors and Survival of Women with Breast Cancer Under 40 Years Old: A Single-Centre Experience. Journal of Clinical Medicine of Kazakhstan. 2020;3(57):39-44.


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