Relationship between gamma-glutamyl transferase/albumin ratio and coronary slow flow phenomenon

Uğur Küçük 1 * , Kadir Arslan 1
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1 Department of Cardiology, Faculty of Medicine, Canakkale Onsekiz Mart University, Canakkale, Turkey
* Corresponding Author
J CLIN MED KAZ, Volume 19, Issue 2, pp. 48-52. https://doi.org/10.23950/jcmk/11940
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ABSTRACT

Aim: The coronary slow flow phenomenon (CSFP) is a pathology characterized by decreased coronary flow without stenosis on angiographic imaging. It is known that gamma-glutamyl transferase (GGT) and albumin play a role in cardiovascular disease. Our aim was to investigate whether GGT-to-albumin ratio could predict CSFP.
Material and methods: Our cross-sectional study included 149 patients who had myocardial ischemia and underwent coronary angiography in our clinic. Our study consisted of two groups, with and without CSFP. The GGT-to-albumin ratio values were compared between the groups, and the presence of a risk factor for CSFP was evaluated with a regression analysis.
Results: A statistical significance was observed between the groups with and without CSFP in terms of GGT-to-albumin ratio values, (6.16 and 4.46, respectively; p<0.001). There was a moderate correlation between GGT-to-albumin ratio and the mean thrombolysis in myocardial infarction frame counts (r=0.423, p<0.001). In the univariate logistic regression analysis revealed that GGT-to-albumin ratio was predictive of CSFP [odds ratio: 0.460, 95% confidence interval (CI): 0.341–0.620, p<0.001]. In the receiver operating characteristic curve analysis performed on GAR to distinguish CSFP, the GGT-to-albumin ratio exhibited 84% sensitivity and 59% specificity for values ≥4.67 (area under the curve: 0.78, 95% CI: 0.708–0.859, p<0.001).
Conclusion: GGT-to-albumin ratio values were found to increase in the presence of CSFP. Our findings advise that GGT-to-albumin ratio might also play a function inside the pathogenesis of CSFP.
Keywords: angiography, coronary slow flow, gamma-glutamyl transferase, gamma-glutamyl transferase to albumin ratio

CITATION

Küçük U, Arslan K. Relationship between gamma-glutamyl transferase/albumin ratio and coronary slow flow phenomenon. J CLIN MED KAZ. 2022;19(2):48-52. https://doi.org/10.23950/jcmk/11940

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