Role of pyroptosis in COVID-19

Mehmet Çelik 1 * , Mehmet Reşat Ceylan 1, Mahmut Alp Karahan 2, İsmail Koyuncu 3, Nevin Güler Dinçer 4, Sevil Alkan 5
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1 Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, University of Harran, Şanlıurfa, Turkey
2 Department of Anesthesiology, Faculty of Medicine, University of Harran, Şanlıurfa, Turkey
3 Department of Medical Biochemistry, Faculty of Medicine, University of Harran, Şanlıurfa, Turkey
4 Department of Statistics, Faculty of Science, University of Muğla Sıtkı Koçman, Muğla, Turkey
5 Department of Infectious Diseases, Faculty of Medicine, Canakkale Onsekiz Mart University, Canakkale, Turkey
* Corresponding Author
J CLIN MED KAZ, Volume 20, Issue 2, pp. 39-45.
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Aim: In this study, we aimed to investigate the relationship between gasdermin-D, caspase-1, IL-1β and NLRP3, biomarkers that play an important role in COVID-19, and pyroptosis.
Material and Methods: This study was carried out with 58 participants, 28 (48.28%) of whom were diagnosis with COVID-19, and 30 (51.72%) of whom were healthy volunteers (control group).
Results: There were no statistically significant differences between the gasdermin-D, caspase-1, IL-1β, and NLRP3 levels as a result of all statistical comparisons performed. However, IL-1β values both during the discharge period and during the hospitalization period were considerably higher than those of the control group. At the discharge period, IL-1β values of the patients with severe COVID-19 category had higher than moderate patients, and the patients with moderate than the patients with mild patients.
Conclusion: It was observed that IL-1β, which is one of the cytokines released as a result of cell death in the pyroptosis mechanism, was higher in the COVID-19 patients in both the hospitalization and discharge periods compared to the control group. Although not statistically significant these results could support the relationship between pyroptosis and COVID-19.


Çelik M, Ceylan MR, Karahan MA, Koyuncu İ, Dinçer NG, Alkan S. Role of pyroptosis in COVID-19. J CLIN MED KAZ. 2023;20(2):39-45.


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