Screening for early lung cancer detection with the low-dose computer tomography

Скрининг раннего рака легкого методом низко-дозной компьютерной томографии
Gulziya Ismailova 1, Raushan Rakhimzhanova 2
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1 National Scientific Medical Research Center, Astana city, Kazakhstan
2 Astana Medical University, Astana city, Kazakhstan
J CLIN MED KAZ, Volume 2, Issue 32, pp. 21-25.
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ABSTRACT

Lung cancer (LC) is the main reason of cancer mortality at around the world.  Shortage of clinical signs of an early stage often leads to diagnostics of LC at late stage.  Current of LC is aggravated by smoking factor which promotes cancer development with heavy KRAS mutation.  LC with KRAS mutation has very bad prognosis, a treatment strategy is only standard, and effective treatment of cancer with KRAS mutation are absent in the world. Overall survival rate is 2-6 months from beginning the clinical manifestations. The only opportunity to increase of the overall survival rate at patient’s cohort is detection of LC at early stage, before clinical manifestations.  Low-dose computer tomography is the most effective screening method for diagnostics of early LC.

Өкпе обыры (ӨО) – бүкіл əлемде обырдан болатын өлім-жітімнің негізгі себебі. Ауруды ерте деңгейінде клиникалық белгілерінің жетіспеушілігі өкпе обырын ең соңғы деңгейінде диагностикалауға жиі соқтырады. Өкпе обыры ағымының ауырлығы шылым шегу факторымен ұлғайтылады, ол ауыр KRAS өзгерумен обырдың дамуына əсер етеді. Өкпе обыры KRAS өзгерумен болжамы өте жаман, стандартты түрдегі химиятерапиямен емдеу, өзгерудің аталмыш түрін емдеудің нəтижелі əдістері бүкіл əлемде əлі жоқ, осындай науқастардың орташа өмір ұзақтығы клиникалық белгілері пайда болу мерзімінен кейін 2-6 ай. Бұл науқастардың өмір ұзақтығын ұзартудың жалғыз мүмкіндігі – ол обырды ерте мерзімінде, клиникалық белгілеріне дейін, анықтау. Төменгі мөлшердегі компьютерлік томография бүкіл əлемде ерте деңгейінде өкпе обырын диагностикалаудың ең нəтижелі скринингтік тəсілі болуда.

CITATION

Ismailova G, Rakhimzhanova R. Screening for early lung cancer detection with the low-dose computer tomography. Journal of Clinical Medicine of Kazakhstan. 2014;2(32):21-5.

REFERENCES

  • Hofman V, et al. Preoperative circulating tumour cell detection using the isolation by size of epithelial tumour cell method for patients with lung cancer is a new prognostic biomarker. Clin Cancer Res 2011; 17: 827-835.
  • Paterlini-Brechot P, Benali NL. Circulating tumour cells (CTC) detection: clinical impact and future directions. Cancer Lett 2007; 253: 180-204.
  • Baigenzhin AK, et al. Сirculating tumour cells: molecular properties and anti-cancer treatment monitoring. J ClinMedKaz 2013;4(30):9-13.
  • Hofman V, et al. Detection of circulating tumour cells as a prognostic factor in patients undergoing radical surgery for non-small cell lung carcinoma: Comparison of the effi cacy of the CellSearch Assay and the isolation by size of epithelial tumour cell method. Int J Cancer 2011;129: 1651-60, 2011.
  • Vona G, et al. Impact of cytomorphological detection of circulating tumour cells in patients with liver cancer. Hepatology 2004; 39: 792-797. 
  • Krebs MG, et al. Evaluation and prognostic signifi cance of circulating tumour cells in patients with non-small-cell lung cancer. J Clin Oncol 2011; 29: 1556-1563.
  • Farace F, et al. A direct comparison of CellSearch and ISET for circulating tumour-cell detection in patients with metastatic carcinomas. Br J Cancer 2011; 105: 847-853.
  • Zh. Hamzabaev. The conteporary condition and perspectives of radial diagnostics development in oncology Astana Medical Journal.2012, No3(71).P.33-35.
  • Gierada D, et al. Lung cancer: interobserver agreement on interpretation of pulmonary fi ndings at low-dose CT. Radiology 2008; 246: 265-72.
  • MacMahon H, et al. Guidelines for management of small pulmonary nodules detected on CT scans: a statement from the Fleischer Society. Radiology 2005; 237: 395-400.
  • Rampinelli C, et al. Accuracy and repeatibility of automatic volume calculation of small pulmonary nodules. Am J Roentgenol 2009; 192: 1657-61.
  • Massimo Bellomi, et al. The wonderful world of pulmonary nodules: an update. Cancer Imaging (2009) 9, S122-S125.
  • Jian-Mei Hou, et al. Circulating Tumor Cells as a Window on Metastasis Biology in Lung Cancer. The American Journal of Pathology, Vol. 178, No. 3, March 2011.
  • International Early Lung Cancer Action Program: Pathology Protocol March 1, 2007 www.IELCAP.org
  • A Lecharpentier, et al. Detection of circulating tumour cells with a hybrid (epithelial/mesenchymal) phenotype in patients with metastatic non-small cell lung cancer. British Journal of Cancer,1–4, September,2011.
  • National Medical Policy // Molecular Tumor Markers for Non-Small Cell Lung Cancer (NSCLC) // Policy Number: NMP206 // Effective Date: November 2010 // Update: September 2011.
  • Daniel B. Costa, et al.Identifi cation of Somatic Genomic Alterations in Circulating Tumors Cells: Another Step Forward in Non–Small-Cell Lung Cancer?Journal of Clinical Oncology, Vol 31, 201.
  • National Medical Policy // Circulating Tumor Cells // Policy Number: NMP 513 // Effective Date: June 2012.
  • Sanja Dacic, et al. Clinicopathological predictors of EGFR/KRAS mutational status in primary lung adenocarcinomas Modern Pathology (2010) 23, 159–168;
  • Stefan Diederich, et al. Screening for Early Lung Cancer with Low-Dose Spiral CT: Prevalence in 817 Asymptomatic Smokers Radiology 2002; 222:773–781
  • Sagawa M.et al. Screening for lung cancer: present and future Gan To Kagaku Ryoho2012 Jan;39(1):19-22.
  • Nolen BM et al. Serum biomarker profiles as diagnostic tools in lung cancer. Cancer Biomark.2011 Jan 1;10(1):3-12.
  • Xiu-yi Zhiet al. Chinese guidelines on the diagnosis and treatment of primary lung cancer (2011) J Thorac Dis. 2012 February; 4(1): 88–101.
  • Larke FJet al. Estimated radiation dose associated with low-dose chest CT of average-size participants in the National Lung Screening Trial.AJR. American Journal of Roentgenology. 2011 Nov;197(5):1165-9.
  • Reddy Cet al. Lung cancer screening: a review of available data and current guidelines. HospPract (Minneap). 2011 Oct;39(4):107-12.
  • Mai He et al. EGFR Exon 19 Insertions: A New Family of Sensitizing EGFR Mutations in Lung Adenocarcinoma Clin Cancer Res; 18(6); 1790–7. 2011
  • Saghir Z et al. CT screening for lung cancer brings forward early disease. The randomized Danish Lung Cancer Screening Trial: status after fi ve annual screening rounds with low-dose CT. Thorax.2012 Apr;67(4):296-301.
  • Smit AA et al. Is lung cancer screening using CT a good idea? Ned TijdschrGeneeskd.2011;155(50):A3960.
  • Spiro SG et al. Screening for lung cancer: Is this the way forward? Respirology.2012 Feb;17(2):237-46.
  • Nobuhiro Kanaji et al. Compensation of type I and type II cytokeratin pools in lung cancer Lung Cancer Volume 55, Issue 3, Pages 295–302, March 2007
  • Hernandez BY, et al. CK20 and CK7 protein expression in colorectal cancer: demonstration of the utility of a population-based tissue microarray. Hum Pathol. 2005 Mar;36(3):275-81.
  • Aubakirova A, et al. Health economic rates for medical services and clinical economic analysis as components of health reform in Kazakhstan. Medical and Health Science Journal/MHSJ/ ISSN: 1804-8884 (Print). 1-7. 2010.
  • Diederich S, et al. Screening for early lung cancer with low-dose spiral CT: prevalence in 817 asymptomatic smokers Radiology. 2002 Mar;222(3):773-81.
  • Duke SL, Eisen T. Finding needles in a haystack: annual low-dose computed tomography screening reduces lung cancer mortality in a high-risk group. Expert Rev Anticancer Ther. 2011 Dec;11(12):1833-6.
  • van ‘t Westeinde SC, et al. The role of conventional bronchoscopy in the work-up of suspicious CT screen detected pulmonary nodules. Chest.2012 Aug;142(2):377-84.
  • Арзыкулов ЖА и др. Заболеваемость раком легкого в Казахстане// Онкология и радиология. 2002.-С.1-8;
  • Бейсебаев АА и др. Реконструктивно-пластические операции в хирургии рака легкого//Вестник КазНМУ. -2010
  • Нургазиев КШ и др. Показатели онкологической службы Республики Казахстан в 2011г. Статистические материалы. Алматы, 201.- 108 с.
  • Шаймарданова ГМ. Перекисное окисление в легких, печени и почках крыс при хронической экспозиции полиметаллической пыли. Успехи современного естествознания Российской Академии Естествознании, 2008.-№8.-С. 28-31.