Serum vitamin D levels in high-risk HPV infected patients, is there any relation?

Anil Turhan Cakir 1 * , Muhammet Atay Ozten 2
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1 Departments of Obstetrics and Gynecology and Gynecologic Oncology, Faculty of Medicine, Zonguldak Bulent Ecevit University
2 Department of Obstetrics and Gynecology, Faculty of Medicine, Zonguldak Bulent Ecevit University
* Corresponding Author
J CLIN MED KAZ, Volume 19, Issue 3, pp. 35-39.
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Objective: Human Papilloma Virus (HPV) is a sexually transmittable virus and is the main etiologic cause of uterine cervical cancers. Beyond that, vitamin D is a steroid structured lipid-soluble vitamin, enhancing both humoral and cellular immune responses. In our study, we aimed to investigate the relationship between vitamin D levels and high-risk HPV infections.
Material and methods: A total of 143 patients who applied to the gynecology outpatient clinic between June 2020 and August 2020 were included in the study. Patients with high-risk HPV positivity constituted the study group, and HPV-negative patients constituted the control group. Serum vitamin D levels were compared between the groups.
Results: The mean vitamin D level of all patients included in the study, HPV(+) and HPV(-) patients were 17.57±8.73, 17.54±9.20 and 17.63±7.83, respectively. In the study group 10.2% of the patients and in the control group 8.5% had adequate vitamin D levels. No significant differences in vitamin D levels and in terms of distribution according to categorical vitamin D level have been observed between the groups (p=0.774, p=0.989).
Conclusion: Vitamin D levels were comparable between HPV positive and HPV negative groups, but study and controls both had very low sufficient vitamin D levels.  In Turkey and especially in our region (Zonguldak), vitamin D deficiency is almost endemic, and this might be the main reason that both of the groups have very similar vitamin D measurements.


Turhan Cakir A, Ozten MA. Serum vitamin D levels in high-risk HPV infected patients, is there any relation?. J CLIN MED KAZ. 2022;19(3):35-9.


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