The Effect of Conscious Sedation on Salivary Alpha-Amylase Levels During Third Molar Surgery

Abdullah Tolga Şitilci 1, Selin Gaş 2 * , Şule Batu 3, Hümeyra Kocaelli Arıkan 4, Büşra Bozbay 5
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1 Department of Anesthesiology and Reanimation, School of Dentistry, Istanbul University, Istanbul, Turkey
2 Department of Oral and Maxillofacial Surgery, School of Dentistry, Beykent University, Istanbul, Turkey
3 Biochemistry Department, School of Dentistry, Istanbul University, Istanbul, Turkey
4 Oral and Maxillofacial Surgery Department, School of Dentistry, Istanbul University, Istanbul, Turkey
5 Orthodontics Department, School of Dentistry, La Sapienze University, Rome, Italy
* Corresponding Author
J CLIN MED KAZ, Volume 2, Issue 56, pp. 11-16.
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Aim: The aim of the present study was to investigate whether salivary alpha-amylase levels could be decreased by conscious sedation in the patients undergoing impacted third molar extraction.
Material and methods: A total of 18 male patients were recruited. All patients were administered the Modified Dental Anxiety Scale test. Patients were divided into a test group (procedures under sedation) and a control group (procedures under local anesthesia). Systolic blood pressure, diastolic blood pressure, oxygen saturation, and heart rate were monitored at different study time-points. Five samples of saliva were taken from each patient: the first time the patient came to the clinic, the patient sat in the chair for extraction, before local anesthesia, immediately after extraction, at 4 h after extraction.
Results: Although no statistically important difference was found for systolic blood pressure (p>0.05) between groups, postoperative diastolic blood pressure level of control group was statistically higher than the test group (p=0.030). Also, a statistically significant decrease was found in the oxygen saturation level in postoperative time compared to preoperative time (p<0.05). 
Conclusion: Even though conscious sedation may be a solution for dental anxiety and phobia, our results indicated that sedation did not affect acute stress levels during oral surgery.


Şitilci AT, Gaş S, Batu Ş, Kocaelli Arıkan H, Bozbay B. The Effect of Conscious Sedation on Salivary Alpha-Amylase Levels During Third Molar Surgery. Journal of Clinical Medicine of Kazakhstan. 2020;2(56):11-6.


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