The Effects Of Surgical Arthroscopy And Intraarticular Medication On The Antioxidant System And Lipid Peroxidation In Knee Osteoarthritis

Idris Perktaş 1 * , Metin Lütfi Baydar 2
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1 Osmaniye Special İbni Sina Hospital, Orthopedic Clinic, Osmaniye, Turkey
2 Orthopedic Clinic, Faculty Of Medicine, Suleyman Demirel University, Isparta, Turkey
* Corresponding Author
J CLIN MED KAZ, Volume 21, Issue 3, pp. 32-36.
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Author Contributions: Conceptualization, İP; methodology, İP; validation, İP; formal analysis, İP; investigation, İP; resources, İP; data curation, İP; writing – original draft preparation, İP; writing – review and editing, İP; visualization, İP; supervision, İP; project administration, İP; funding acquisition, MLB. The author has read and agreed to the published version of the manuscript.


Aim: This study aims to evaluate the effects of joint surgery through arthroscopy, intraarticular medication, and antioxidant therapy on the antioxidant system and lipid peroxidation in patients with knee osteoarthritis (KOA). The study examines the ability of high-molecular weight hyaluronan, sodium hyaluronate, and oral Vitamin E to modulate oxidative stress markers in the knee joint.
Methods and Materials: There were 60 patients diagnosed with KOA that were divided into four groups according to the type of treatment for this prospective study at the Department of Orthopaedics and Traumatology. Blood and synovial fluid samples collected before and after treatment were evaluated for superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), lipid peroxidation (malondialdehyde, MDA) catalase (CAT). SPSS software was used to perform statistical analysis where the significance level was set at p<0.05.
Results: Synovial fluid malondialdehyde levels that showed a decreased tendency among treated groups indicated a reduced state of antioxidant activity. However, no significant changes were observed in systemic oxidative stress markers. These findings show that localized antioxidant therapy within the knee can be effective in reducing oxidative stress, therefore, may have implications for nonsurgical treatment of KOA.
Conclusion: The results emphasize possible gains made from combining surgical arthroscopy together with antioxidant treatment in managing KOA. By reducing the level of oxidative stress within the knee joint, this combined method can provide a viable solution to improve symptoms and quality of life among KOA patients.


Perktaş I, Baydar ML. The Effects Of Surgical Arthroscopy And Intraarticular Medication On The Antioxidant System And Lipid Peroxidation In Knee Osteoarthritis. J CLIN MED KAZ. 2024;21(3):32-6.


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